Applications of NMR spectroscopy based metabolomics: a review
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초록
Metabolomics is the study which detects the changes of metabolites level. Metabolomics is a terminal view of the biological system. The end products of the metabolism, metabolites, reflect the responses to external environment. Therefore metabolomics gives the additional information about understanding the metabolic pathways. These metabolites can be used as biomarkers that indicate the disease or external stresses such as exposure to toxicant. Many kinds of biological samples are used in metabolomics, for example, cell, tissue, and bio fluids. NMR spectroscopy is one of the tools of metabolomics. NMR data are analyzed by multivariate statistical analysis and target profiling technique. Recently, NMR-based metabolomics is a growing field in various studies such as disease diagnosis, forensic science, and toxicity assessment.
Abstract
Metabolomics is the study which detects the changes of metabolites level. Metabolomics is a terminal view of the biological system. The end products of the metabolism, metabolites, reflect the responses to external environment. Therefore metabolomics gives the additional information about understanding the metabolic pathways. These metabolites can be used as biomarkers that indicate the disease or external stresses such as exposure to toxicant. Many kinds of biological samples are used in metabolomics, for example, cell, tissue, and bio fluids. NMR spectroscopy is one of the tools of metabolomics. NMR data are analyzed by multivariate statistical analysis and target profiling technique. Recently, NMR-based metabolomics is a growing field in various studies such as disease diagnosis, forensic science, and toxicity assessment.
참고문헌 (43)
- A. Roux, , Clinical Biochemistry, 44, pp.119~ (2011)
- R.D. Beger, , Toxicol Appl Pharmacol, 243, pp.154~ (2010)
- J.K. Nicholson, , Xenobiotica, 29, pp.1189~ (1999)
- D.A. Bennett, , Environ Health Perspect, 108, pp.907~ (2000)
- Biomarkers Definitions Working Group, , Clin Pharmacol Ther, 69, pp.89~ (2001)
- J.A. Timbrell, , Toxicology, 129, pp.1~ (1998)
- J.K. Nicholson, , Nat. Rev. Drug Discov, 1, pp.123~ (2002)
- A. Zhang, , JOURNAL OF PROTEOMICS, 75, pp.1079~ (2012)
- J.K. Nicholson, , Nature, 455, pp.1054~ (2008)
- H. Wang, , Future Oncol, 6, pp.1395~ (2010)
- R. Madsena, , Analytica Chimica Acta, 659, pp.23~ (2010)
- O.A.H. Jones, , Chemosphere, 71, pp.601~ (2008)
- G.Sudama, , Metabolomics, 9, pp.189~ (2013)
- R.Tyagi, , Metabolomics, 8, pp.940~ (2012)
- R.D. Beger, , Metabolomics, 8, pp.2~ (2012)
- A. Zhang, , Anal Bioanal Chem, 404, pp.1239~ (2012)
- J.G. Bundy, , Metabolomics, 5, pp.3~ (2009)
- S.C. Gates, , 24, pp.1663~ (1978)
- 김석만, "Syndecan-4 cytoplasmic domain could disturb the multilamellar vesicle", Journal of the Korean Magnetic Resonance Society, 13(1), pp.1~6 (2009), 한국자기공명학회
- J.L. Spratlin, , Clin Cancer Res, 15, pp.431~ (2009)
- J.L. Griffin, , Nat Rev Cancer, 4, pp.551~ (2004)
- A.M. Emwas, , Metabolomics[DOI]
- S. Rehman, , Molecular Biosystems, 8, pp.2274~ (2012)
- A.E.S.I. Ahmed, , Journal of Applied Polymer Science, 119, pp.709~ (2011)
- L. Corte, , Analytica Chimica Acta, 659, pp.258~ (2010)
- J.K. Nicholson, , Progress in Nuclear Magnetic Resonance Spectroscopy, 21, pp.449~ (1989)
- D. G. Robertson, , TOXICOLOGICAL SCIENCES, 85, pp.809~ (2005)
- R.S. Plumb, , Mass Spectrom, 16, pp.1991~ (2002)
- N.V. Reo, , Drug Chem. Toxicol, 25, pp.375~ (2002)
- D. S. Wishart, , Trends in Analytical Chemistry, 27, pp.228~ (2008)
- D.M. Wilson, , Biochem. Biophys. Res. Commun, 56, pp.828~ (1974)
- R.G. Shulman, , Annu. Rev. Physiol, 65, pp.401~ (2003)
- M.W. Weiner, , NMR Biomed, 2, pp.290~ (1989)
- J.K. Nicholson, , Nat. Rev. Drug Discov, 2, pp.668~ (2003)
- J. Trygg, , J. Proteome Res, 6, pp.469~ (2007)
- H. Serrai, , NMR Biomed, 11, pp.273~ (1998)
- M. Ala-Korpela, , Atherosclerosis, 190, pp.352~ (2007)
- J.R. McNamara, , Clin. Chim. Acta, 369, pp.158~ (2006)
- S.W. Provencher, , Magn. Reson. Med, 30, pp.672~ (1993)
- B.C. Sweatman, , Biomed. Anal, 11, pp.651~ (1993)
- Hee-Eun Kim, "Metabolic classification of herb plants by NMR-based metabolomics", Journal of the Korean Magnetic Resonance Society, 16(2), pp.91~102 (2012), 한국자기공명학회[DOI]
- 채영기, "Metabolic Profiling of Urine Samples from Colorectal Cancer Patients Before and After Surgical Treatments", Journal of the Korean Magnetic Resonance Society, 14(1), pp.28~37 (2010), 한국자기공명학회
- 김시원, "Study of Metabolic Profiling Changes in Colorectal Cancer Tissues Using 1D 1H HR-MAS NMR Spectroscopy", Bulletin of the Korean Chemical Society, 34(5), pp.1467~1472 (2013), 대한화학회