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반하후박탕(半夏厚朴湯)의 사회ㆍ심리적 스트레스에 대한 실험적 연구(實驗的 硏究)

Effects of Banhahubak-Tang Extract (BHTe) on Sociopsychological Stress

김하나|김경옥|송영길|원호영
대한한방신경정신과학회 (The Korean Society Of Oriental Neuropsychiatry)|2014.09|동의신경정신과학회지 (The Korean Society of Oriental Neuropsychiatry)|제25권 제3호|pp. 297-310

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참고문헌

키워드

Lipid peroxidationCorticosteroneNoradrenalinBanhahubak-Tang extract (BHTe)Sociopsychological stressAnti-anxiety effect.
주제분류한의학

초록

Objectives: This study is designed to investigate the effects of Banhahubak-Tang Extract (BHTe) on stress.Methos: BHTe was fed to ICR male mice (20±2 g) orally with the dose of 100 mg/kg/day for five days. Mice were then exposed to sociopsychological stress by observing foot shock stressed mice for one hour for five days while restrained.Results: 1) The BHTe-administered group showed a tendency of decreasing of serum corticosterone secretion compared with the control group. 2) The BHTe-administered group showed an increase in noradrenalin secretions in the dorsal cortex of the brain, but it was not significant. 3) BHTe admin-istration had no effect on the brain level of lipid peroxidation. 4) BHTe administration decreased the serum level of lipid peroxidation. 5) BHTe administration decreased the Cu,Zn-SOD in the brain. 6) BHTe administration had no effect on catalase activity in the brain. 7) BHTe administration had no effect on the brain level of GSH. 8) BHTe administration increased the serum level of DPPH free radical scaveng-ing activity, but not significantly enough to make a comparison with BHT. 9) The elevated plus-maze test is designed to detect the effect of anxiolytic drugs. The BHTe group showed a significant increase in latency time.Conclusions: These results suggest that BHTe can effectively rid the subject of the effects of socio-psychological stress.

Abstract

Objectives: This study is designed to investigate the effects of Banhahubak-Tang Extract (BHTe) on stress.Methos: BHTe was fed to ICR male mice (20±2 g) orally with the dose of 100 mg/kg/day for five days. Mice were then exposed to sociopsychological stress by observing foot shock stressed mice for one hour for five days while restrained.Results: 1) The BHTe-administered group showed a tendency of decreasing of serum corticosterone secretion compared with the control group. 2) The BHTe-administered group showed an increase in noradrenalin secretions in the dorsal cortex of the brain, but it was not significant. 3) BHTe admin-istration had no effect on the brain level of lipid peroxidation. 4) BHTe administration decreased the serum level of lipid peroxidation. 5) BHTe administration decreased the Cu,Zn-SOD in the brain. 6) BHTe administration had no effect on catalase activity in the brain. 7) BHTe administration had no effect on the brain level of GSH. 8) BHTe administration increased the serum level of DPPH free radical scaveng-ing activity, but not significantly enough to make a comparison with BHT. 9) The elevated plus-maze test is designed to detect the effect of anxiolytic drugs. The BHTe group showed a significant increase in latency time.Conclusions: These results suggest that BHTe can effectively rid the subject of the effects of socio-psychological stress.

참고문헌 (67)

  1. Lee BY, "Psychiatric Dictionary", pp.272~ (1990), Ilchokak
  2. Park YE, "A Study on Socio-psychological Stresses Affected with Health Status", Korean journal of health education and promotion, 16(1), pp.61~63 (1990)
  3. Kwon SM, "Contemporary Abnormal Psychology", pp.99~ (2003), Hakjisa
  4. Stone, E. A., "Cathecholamines and Behavior", pp.31~72 (1975), Plenum Press
  5. Korean Neuropsychiatric Association, "Neuropsychiatric", pp.465~469 (1998), Hana Medicine Publisher
  6. Lee KH, "Modern Clinical Psychiatry", pp.498~500 (1985), Hana Medicine Publisher
  7. Luthans F., "Organizational Behavior", pp.130~ (1985), Mogrew-Hill
  8. Robbins S., "Drganizational Behavior, Concept, Controversies and applications", pp.385~ (1986), Prentice-Hall
  9. Kwon BH, "Effect of Samulanshin-tang on Rats stressed by Immobilization", Journal of Oriental Neuropsychiatry, 5(1), pp.86~ (1994)
  10. Hong WS, "Oriental Natural Medicine", pp.158~286 (1985), 309Institute Press
  11. Chen Y., "Chenmozhai Sanyinfang 2quan", pp.6~ (1978), Taibeiguofengchubanshe
  12. Moon JJ, "Oriental Medical Pathology", pp.23~79 (1990), Komoonsa
  13. Kim JW, "Stress in Oriental Medicine", Journal of The Korean Society of Stress Medicine, 1(1), pp.120~121 (1993)
  14. Hwang EW, "Psychosomatic Disease", pp.18~44 (1985), Heunglim publishing company
  15. Hwang EW, "Dongeui psychiatry", pp.99~109 (1987), Hyundai medical publishing company
  16. Kim YS, "The Experimental Study on the Anti-stress Effect of Bohyulansin-tang on Noise stress", Doctor, pp.1986
  17. Lee DJ, "The Experimental Study on the Anti-stress Effect of Bohyulansin-tang and Gamibohyulansin-tang", Doctor, pp.1987
  18. Kang HK, "Effect of Jaeumgunbi-tang on the Gastric Ulcer and Plasma Catecholamines Contents of Rats in Immobilization Stress", Doctor, pp.1992
  19. Ji SY, "An Experimental Study on the Change of Stress-related Hormone Contents by Prescription of Bunsim-gieum", Journal of Oriental Neuropsychiatry, 3(2), pp.49~63 (1992)
  20. Whang CY, "Effect of Sibjeondaebo-tang adding Cervi Pantotrichum Cornu on Immune Response in Mouse", Doctor, pp.1989
  21. Lim DS, "The Anti-stress Effect of Semenziziphi Spinosae Extract", Master, pp.2003
  22. Kim EJ, "Dongshin University Graduate School Doctorate thesis", Doctor, pp.2005
  23. Choi JH, "Dongshin University Graduate School Doctorate thesis", Doctor, pp.2005
  24. 김경호, "Effects of Radix Polygalae Extract on Sociopsychological Stress", 대한본초학회지, 18(1), pp.12~108 (2003), 대한본초학회
  25. 조수인, "石菖蒲 추출물이 생쥐의 사회ㆍ심리적 스트레스에 미치는 영향", 대한본초학회지, 19(4), pp.1~8 (2004), 대한본초학회
  26. Zhang ZH, "Xinbianzhangjingquanshu Jinguiyaoluepian", pp.66~ (1993), Dsprinter
  27. Lee SI, "Fangjixue", pp.382~ (1999), Yonglinshe
  28. Kang JM, "Experimental Studies on Anti-tumor and Immunodulatory Effects of Banhahoobak-tang", The Journal of Korean Oriental Oncology, 2(1), pp.57~73 (1996)
  29. Lee BK, "Experimental Studies on Pharmacological Action of the Banhahoobak-tang, A Combined Preparation of Oriental Medicine", The Korean Journal of Pharmacognosy, 18(1), pp.14~25 (1987)
  30. Ogawa N, "Psychophysiology of emotion-communication of emotion", Jpn J Psychosom Med, 6, pp.352~357 (1996)
  31. Shibasaki T, "Psychological stress increases arousal through brain corticotropin-releasing hormone without significant increase in adrenocorticotropin and catecholamine secretion", Brain Res, 618, pp.71~75 (1993)
  32. Zenker N, , J. Biol. Chem, 69, pp.231~ (1958)
  33. Kohno Y, "Simultaneous determination of noradrenaline and 3-methoxy-4hydroxy- phenylethylene-glycol sulfatein discrete brain regions of the rat", Anal Biochem, 97, pp.352~358 (1979)
  34. Uchiyama M., "Determination of malonaldehyde precusor in tissue by thiobarbituric acid test", Anal. Biochem, 86, pp.271~278 (1987)
  35. Bradford M. M., "A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dry binding", Anal. Biochem, 72, pp.248~524 (1976)
  36. Fridovich I, "The role of superoxide anion in the autooxidation of epinephrine and a simple assay for superoxide dismutase", J. Biol. Chem, 247, pp.3170~3175 (1972)
  37. Aebi HE, "Methods of enzymatic analysis", pp.273~286 (1987), VCH Verlagsggesellschaft
  38. Anderson ME, "Determination of glutathione and glutathione disulfide in biological samples", Methods Enzymol, 113, pp.548~554 (1985)
  39. A Study on the Activating Plan of the Local Council on Social Welfare, "Byun JH", Korea Institute for Health and Social Affairs, ~ (1977)
  40. Schnake M, "Human Relations", pp.280~ (1990), Merrill Publ
  41. Dalton M., "Human Relations", pp.408~ (1992), South western Publ
  42. Cannon WB, "Bodily changes in pain, hunger, fear and rage" (1936), Appleton-Century
  43. Seley H, "The alarm reaction", Can Med Assoc J, 34, pp.706~711 (1936)
  44. Selye H., "Forty years of stress research. Principal remaining problems and misconceptions", Can Med Assoc J, 115, pp.53~56 (1976)
  45. Hong DS., "Introduction of Psychology", pp.603~608 (1992), Pakyoungsa
  46. Holmes T. H., "The Social Readjustment rating scale", Journal of Psychosomatic Research, 11, pp.213~218 (1967)
  47. Lazarus R. S, "Psychological stress and the coping process" (1966), Mc Grew-Hill
  48. Lazarus R. S., "Psychological stress and coping in aging", American Psychologist, 38, pp.245~254 (1983)
  49. Jeon KK, "A Step toward an Integrative Model of Stress and Coping: A Contral Theory Approach", The Korean Journal of Psychology, pp.34~65 (1996)
  50. Korean Psychological Association, "Understanding of Contemporary Psychology", pp.612~622 (2006), Hakmun Publisher
  51. Yang BH, "The Study on Stress", pp.29~ (1999), Hana Medicine Publisher
  52. Apples A., "A questionnaire to assess premonitory symptoms of myocadial infarction", International Journal of Cardiology, 17, pp.15~24 (1987)
  53. Kim SH., "Dongeui neuropsychiatry", pp.152~284 (1978), Heanglim publishing company
  54. She YJ., "Zhongyi naikexue", pp.141~142 (1985), Sichuenkexuejishuchubanshe
  55. Jiang KM, "Jiaodingfangjidaicidian", pp.24~348 (1991), Euisungdang
  56. The Whole Korean medicine Bonchohak professor Coedition, "Bonchohak", pp.125~449 (1992), Younglimsa
  57. Kang BS, "Yimsan Baehap Bonchohak", pp.363~574 (1994), Younglimsa
  58. Anisman H., "Depression : The predisposing influence of stress", Behavior Brain Science, 5, pp.89~137 (1982)
  59. Hoyenga K. B., "Psychobiology: The Neuron and behavior" (1988), Books-Cole publishing company
  60. Sapolsky R., "Stress and Glucocorticonoids in Aging", Endocrinology and Metabolic Clinics, 16(4), pp.965~980 (1987)
  61. Maria Konstandi, "Noradrenaline, dopamine, seretonin: different effects of psychological stress on brain biogenic amines in mice and rats", Pamachological Research, 41(3), pp.341~346 (2000)
  62. Kim SH, "Effects of the Ansymondam-tang and Gamiondam-tang on the Regional Brain Monoamines Contents of Swimming Stressed Mice", Journal of Oriental Neuropsychiatry, 12(1), pp.97~109 (2001)
  63. Cho KH, "Effects of the Guibi-tang and Yishingyojaedan on the Regional Brain Monoamines Contents of Immobilization Stressed Mice", Journal of Oriental Neuropsychiatry, 12(1), pp.111~122 (2001)
  64. Choi BK, "Reactive Oxygen Substances and Disease", pp.53~254 (2004), Shinil Publisher
  65. Lee KN, "Clinical Pathology", pp.345~404 (2000), Medicine Publisher
  66. Yagi K, "Lipid peroxides and human disease", Chemistry and Physics of Lipids, 45, pp.337~351 (1987)
  67. Song KJ, "Psychology of Life", pp.317~321 (1998), Hakmun Publisher

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半夏厚朴湯이 생쥐의 심리적 스트레스에 미치는 영향과 유전자 분석김경수, 김경옥, 박수연, 양승정, 위통순, 조수인, 최금애, 최창원대한한방신경정신과학회 · 동의신경정신과학회지2015 · 제26권 제2호半夏 추출물이 생쥐의 사회·심리적 스트레스에 미치는 영향김경옥, 김수연, 임세현, 조수인, 최창원대한한방신경정신과학회 · 동의신경정신과학회지2009 · 제20권 제3호우울증 생쥐 모델에서 半夏厚朴湯加味의 항우울 효과김국기, 이상룡, 정인철대한한방신경정신과학회 · 동의신경정신과학회지2014 · 제25권 제2호大黃, 黃連 및 大黃黃連寫心湯이 구속스트레스 부하 ICR-mouse의 스트레스 환경에서의 회복능력에 미치는 영향강형원, 김향이, 류영수, 박현제, 서주희, 이효경대한한방신경정신과학회 · 동의신경정신과학회지2011 · 제22권 제1호생쥐에서 치자시탕(梔子豉湯)의 항스트레스 효과에 대한 연구강형원, 김재효, 류영수, 이고은, 정세인대한한방신경정신과학회 · 동의신경정신과학회지2017 · 제28권 제3호후박의 항우울 효과에 대한 실험적 연구우찬, 유주연, 이언정, 정혜련, 최정훈대한한방내과학회 · 대한한방내과학회지2013 · 제34권 제3호

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