파킨슨병으로 인한 우울증의 한의 임상연구 고찰
A Review of Clinical Studies on Depression Caused by Parkinson’s Disease in Traditional Korean Medicine
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Objectives: Parkinson’s disease is a degenerative neurological disorder caused by dopamine neuron damage, leading to various motor and non-motor symptoms, including depression. While several clinical studies on Traditional Korean Medicine (TKM) have addressed this issue, no comprehensive review has been conducted. This study aimed to summarize and analyze TKM treatments for depression associated with Parkinson’s disease. Methods: This study reviewed research focused on treatment of Parkinson’s-related depression, particularly examining traditional therapies such as acupuncture and herbal medicine. Data on treatment methods were analyzed to compare approaches of control and experimental groups. Specific use of acupuncture points and other TKM treatments was analyzed. Results: Out of 57 studies, 17 involving 649 participants were selected. Various treatment methods were evaluated, primarily using the Unified Parkinson’s Disease Rating Scale (UPDRS). Studies predominantly focused on acupuncture targeting specific points (such as LI 4, GB 20, and ST 36) and the use of various herbal medicine combinations. Conclusions: Of the 17 studies, 13 focused on effects of acupuncture, suggesting that acupuncture might play a significant role in alleviating depression associated with Parkinson’s disease. Specifically, the use of acupuncture points such as LI 4, GB 20, and ST 36 showed potential therapeutic effects. Additionally, 13 studies demonstrated that TKM could significantly alleviate depression, indicating the potential for an integrative approach combining Eastern and Western therapies. Herbal medicine and Qigong dance therapy also showed promising effects in improving depression.
Abstract
Objectives: Parkinson’s disease is a degenerative neurological disorder caused by dopamine neuron damage, leading to various motor and non-motor symptoms, including depression. While several clinical studies on Traditional Korean Medicine (TKM) have addressed this issue, no comprehensive review has been conducted. This study aimed to summarize and analyze TKM treatments for depression associated with Parkinson’s disease. Methods: This study reviewed research focused on treatment of Parkinson’s-related depression, particularly examining traditional therapies such as acupuncture and herbal medicine. Data on treatment methods were analyzed to compare approaches of control and experimental groups. Specific use of acupuncture points and other TKM treatments was analyzed. Results: Out of 57 studies, 17 involving 649 participants were selected. Various treatment methods were evaluated, primarily using the Unified Parkinson’s Disease Rating Scale (UPDRS). Studies predominantly focused on acupuncture targeting specific points (such as LI 4, GB 20, and ST 36) and the use of various herbal medicine combinations. Conclusions: Of the 17 studies, 13 focused on effects of acupuncture, suggesting that acupuncture might play a significant role in alleviating depression associated with Parkinson’s disease. Specifically, the use of acupuncture points such as LI 4, GB 20, and ST 36 showed potential therapeutic effects. Additionally, 13 studies demonstrated that TKM could significantly alleviate depression, indicating the potential for an integrative approach combining Eastern and Western therapies. Herbal medicine and Qigong dance therapy also showed promising effects in improving depression.
참고문헌 (36)
- Ha JY, "The Effect of Manual Acupuncture Therapy on Symptoms of the Patients with Idiopathic Parkinson’s Disease", J Korean Med, 24(3), pp.172~183 (2003)
- Lee JH, "The frequency of depression and its effects in idiopathic Parkinson’s disease", J Korean Neurol Assoc, 13(3), pp.574~583 (1995)
- Lee SY, "Report on the Case Study of Parkinson’s Syndrome Patients Visited to Korean Oriental Hospital", Korean Journal of Joongpoong, 8(1), pp.34~39 (2007)
- "Statistics on Diseases of Public Interest" (2024)[URL]
- Li Q, "Effect of acupuncture for non-motor symptoms in patients with Parkinson’s disease: A systematic review and meta-analysis", Front Aging Neurosci (2022)[DOI]
- Park SW, "A carbon quantum dot-based fluorescent biosensor for sensitive and selective detection of levodopa", pp.2021
- Yang DH, "A Study on the Effect of Acupuncture on the Side Effects of Gastrointestinal System in Levodopa Drugs-Patients with idiopathic Parkinson’s Disease", J Acupunct Res, 27(6), pp.11~21 (2010)
- Faingold CL, "Electrical stimulation therapies for CNS disorders and pain are mediated by competition between different neuronal networks in the brain", Med Hypotheses, 71(5), pp.668~681 (2008)[DOI]
- Chen FP, "A clinical study of integrating acupuncture and Western medicine in treating patients with Parkinson’s disease", Am J Chin Med, 43(3), pp.407~423 (2015)[DOI]
- Yeo S, "A study of the effects of 8-week acupuncture treatment on patients with Parkinson’s disease", Medicine(Baltimore), 97(50), pp.e13434~ (2018)[DOI]
- Iseki C, "Acupuncture alleviated the nonmotor symptoms of Parkinson’s disease including pain, depression, and autonomic symptoms", Case Rep Neurol Med, 2014, pp.953109~ (2014)[DOI]
- Kong KH, "Acupuncture in the treatment of fatigue in Parkinson’s disease : A pilot, randomized, controlled, study", Brain Behav, 8(1), pp.e00897~ (2017)[DOI]
- Shulman LM, "Acupuncture therapy for the symptoms of Parkinson’s disease", Mov Disord, 17(4), pp.799~802 (2002)[DOI]
- Wang F, "Effect and potential mechanism of electroacupuncture add-on treatment in patients with Parkinson’s disease", Evid Based Complement Alternat Med, 2015, pp.692795~ (2015)[DOI]
- Jang JH, "Effectiveness and Therapeutic Mechanism of Pharmacopuncture for Pain in Parkinson’s Disease : A Study Protocol for a Pilot Pragmatic Randomized, Assessor-Blinded, Usual Care-Controlled, Three-Arm Parallel Trial", International Journal of Environmental Research and Public Health, 20(3), pp.1776~ (2023)[DOI]
- Cho SY, "Effectiveness of acupuncture and bee venom acupuncture in idiopathic Parkinson’s disease", Parkinsonism Relat Disord, 18(8), pp.948~952 (2012)[DOI]
- Kang DH, "Efficacy and safety of a combination of emotional freedom technique with acupuncture versus acupuncture alone to treat psychiatric symptoms in Parkinson’s disease : A protocol for a randomized, assessor-blind, parallel-group clinical trial", Medicine(Baltimore), 102(21), pp.e33714~ (2023)[DOI]
- Cho SY, "Efficacy of combined treatment with acupuncture and bee venom acupuncture as an adjunctive treatment for Parkinson’s disease", J Altern Complement Med, 24(1), pp.25~32 (2018)[DOI]
- Cristian A, "Evaluation of acupuncture in the treatment of Parkinson’s disease : a double-blind pilot study", Mov Disord, 20(9), pp.1185~1188 (2005)[DOI]
- Xu Y, "Madopar combined with acupuncture improves motor and non-motor symptoms in Parkinson’s disease patients : A multicenter randomized controlled trial", Eur J Integr Med, 34, pp.101049~ (2020)[DOI]
- Wu C, "Moxibustion treatment for Parkinson’s disease : study protocol for a randomized controlled trial", BMC Complement Med Ther, 23(1), pp.193~ (2023)[DOI]
- Roh MY, "A case report in which the non-motile symptoms evaluated by the Non-Motor Symptom Scale(NMSS)in a patient with secondary Parkinson’s disease, which is presumed to be Lewy body dementia, were improved with a combination of herbal medicine and acupuncture", J Korean Acad Orient Med, 42(5), pp.833~845 (2021)[DOI]
- Kim YJ, "A case of oriental medicine trial in a patient with weak Parkinson’s syndrome", J Korean Acad Orient Med, 37(2), pp.381~388 (2016)
- Doo KH, "A prospective open-label study of combined treatment for idiopathic Parkinson’s disease using acupuncture and bee venom acupuncture as an adjunctive treatment", J Altern Complement Med, 21(10), pp.598~603 (2015)[DOI]
- Lee HJ, "Turo(Qi Dance)Program for Parkinson’s Disease Patients : Randomized, Assessor Blind, Waiting-List Control, Partial Crossover Study", Explore(NY), 14(3), pp.216~223 (2018)[DOI]
- Filshie Jacqueline, "Medical Acupuncture: A Western Scientific Approach", pp.734~ (2016), Elsevier
- Kang HS, "Two trials applying a combination of acupuncture and meditation for depressed patients who complain of physical symptoms as their main symptoms", J Assoc Neuropsychiatry Dong, 19(2), pp.241~250 (2008)
- Korean Medical University and the Graduate School of Oriental Medicine Compilation Committee for Contribution to Transfusion Textbooks, "Transfusion of Transfusion (1)", pp.760~ (2020), JEONGDAM
- Korean Medical University and the Graduate School of Oriental Medicine Compilation Committee for Contribution to Transfusion Textbooks, "Transfusion of Transfusion(2)", pp.756~ (2020), JEONGDAM
- Terawaki T, "Partial agonistic effect of Yokukansan on human recombinant serotonin 1A receptors expressed in the membranes of Chinese hamster ovary cells", J Ethnopharmacol, 127, pp.306~312 (2021)[DOI]
- Egasira N, "Repeated administration of Yokukansan inhibits DOI-induced head-twitch response and decreases expression of 5-hydroxytryptamine(5-HT)2A receptors in the prefrontal cortex", Prog Neuropsychopharmacol Biol Psychiatry, 32, pp.1516~1520 (2008)[DOI]
- Lee HY, "The effect of Yanggyeoksanhwatang on nerve cell damage caused by ischemic damage to brain hippocampal tissue culture", J Korean Acad Orient Med, 29(1), pp.231~242 (2008)
- Jang YS, "Production of endogenous neurons in the brain after birth", Korean J Pediatr, 48(8) (2005)
- He X, "Effects of a 16-week dance intervention on the symptom cluster of fatiguesleep disturbance-depression and quality of life among patients with breast cancer undergoing adjuvant chemotherapy : A randomized controlled trial", Int J Nurs Stud, 133, pp.104317~ (2022)[DOI]
- Rios Romenets S, "Tango for treatment of motor and non-motor manifestations in Parkinson’s disease : a randomized control study", Complement Ther Med, 23(2), pp.175~184 (2015)[DOI]
- Michels K, "Dance Therapy as a psychotherapeutic movement intervention in Parkinson’s disease", Complement Ther Med, 40, pp.248~252 (2018)[DOI]