Association between Fasting Blood Glucose Levels and Arterial Stiffness in Healthy Korean Men and Women
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Background: Increased fasting blood glucose (FBG) level and obesity can be associated with the progression of arterial stiffness, which is an early marker of atherosclerosis. Measuring pulse wave velocity (PWV) is a non-invasive method to evaluate vessel wallstiffness. Objective: The objective was to determine the association of FBG levels and obesity with peripheral PWV considering insulin resistance. Methods: Across-sectional study was conducted in 2006. Waist circumference (WC), body mass index (BMI), and PWV were measured in 3,390 healthy Korean men and women. Multiple linear regression mod- els were used to assess the association between FBG levels and peripheral PWV. The population was classi- fied into two groups according to median insulin resistance values (homeostasis model assessment of insulin resistance [HOMA-IR]). Results: Peripheral PWV was significantly associated with BMI and systolic blood pressure in men and women, respectively, after adjusting for age, lipid levels, and HOMA-IR (Table 3). WCwas associated with peripheral PWV only in women ( p =0.006). The relationship between peripheral PWV and FBG in women was significant in subjects with HOMA-IR < 0.725 ( p = 0.015). Conclusions: These results suggest that FBG levels and waist circumference are associated with peripheral PWV in Korean women. Further studies should be performed in other populations to confirm the associa- tion between FBG levels and PWV considering insulin resistance.
Abstract
Background: Increased fasting blood glucose (FBG) level and obesity can be associated with the progression of arterial stiffness, which is an early marker of atherosclerosis. Measuring pulse wave velocity (PWV) is a non-invasive method to evaluate vessel wallstiffness. Objective: The objective was to determine the association of FBG levels and obesity with peripheral PWV considering insulin resistance. Methods: Across-sectional study was conducted in 2006. Waist circumference (WC), body mass index (BMI), and PWV were measured in 3,390 healthy Korean men and women. Multiple linear regression mod- els were used to assess the association between FBG levels and peripheral PWV. The population was classi- fied into two groups according to median insulin resistance values (homeostasis model assessment of insulin resistance [HOMA-IR]). Results: Peripheral PWV was significantly associated with BMI and systolic blood pressure in men and women, respectively, after adjusting for age, lipid levels, and HOMA-IR (Table 3). WCwas associated with peripheral PWV only in women ( p =0.006). The relationship between peripheral PWV and FBG in women was significant in subjects with HOMA-IR < 0.725 ( p = 0.015). Conclusions: These results suggest that FBG levels and waist circumference are associated with peripheral PWV in Korean women. Further studies should be performed in other populations to confirm the associa- tion between FBG levels and PWV considering insulin resistance.
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