신규 고혈압 환자의 치료지속성 추이와 관련 요인
Medication Adherence Trends and its Related Factors in Newly Diagnosed Hypertensive Patients
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Objectives: This study aimed to examine medication adherence in newly diagnosed hypertensive patients and to investigate factors affecting their medication adherence. Methods: The present study used sample cohort database (DB) 2.0 provided by National Health Insurance Service and assessed 7,294 subjects meeting the inclusion criteria. The proportion of medication adherent and 8-year medication possession ratios (MPRs) according to general characteristics of subjects were analyzed. In addition, multiple regression and logistic regression analyses were used to examine relationship between MPR and medication adherence with its associated factors. All statistical analyses were completed with SAS statistical software version 9.4 (SAS Institute Inc., Cary, NC, USA) and p-value <0.05 was considered to indicate statistical significance. Results: The proportion of medication adherent increased from 64.5% in the 1st year to 67.9% in the final follow-up year (maximum in the 7th year, 68.1%). Mean MPRs according to general characteristics of subjects were the lowest in the 2nd-3rd year. Medication adherence in newly diagnosed hypertensive patients was associated with age, complication, and MPR in the 1st year. The regression analyses suggested that MPR in the 1st year explained both the final and overall follow-up medication adherence 12.9% and 37.4%, respectively. In addition, medication adherents in the 1st year were more likely to remain as so in the final year (odds ratio, OR= 3.48). Conclusions: The findings suggested medication adherence in the early year of diagnosis is associated with the final and overall medication adherence in newly diagnosed hypertensive patients. It is necessary for medical institution and community to work together to establish education system for patients with hypertension at the initial stage of diagnosis.
Abstract
Objectives: This study aimed to examine medication adherence in newly diagnosed hypertensive patients and to investigate factors affecting their medication adherence. Methods: The present study used sample cohort database (DB) 2.0 provided by National Health Insurance Service and assessed 7,294 subjects meeting the inclusion criteria. The proportion of medication adherent and 8-year medication possession ratios (MPRs) according to general characteristics of subjects were analyzed. In addition, multiple regression and logistic regression analyses were used to examine relationship between MPR and medication adherence with its associated factors. All statistical analyses were completed with SAS statistical software version 9.4 (SAS Institute Inc., Cary, NC, USA) and p-value <0.05 was considered to indicate statistical significance. Results: The proportion of medication adherent increased from 64.5% in the 1st year to 67.9% in the final follow-up year (maximum in the 7th year, 68.1%). Mean MPRs according to general characteristics of subjects were the lowest in the 2nd-3rd year. Medication adherence in newly diagnosed hypertensive patients was associated with age, complication, and MPR in the 1st year. The regression analyses suggested that MPR in the 1st year explained both the final and overall follow-up medication adherence 12.9% and 37.4%, respectively. In addition, medication adherents in the 1st year were more likely to remain as so in the final year (odds ratio, OR= 3.48). Conclusions: The findings suggested medication adherence in the early year of diagnosis is associated with the final and overall medication adherence in newly diagnosed hypertensive patients. It is necessary for medical institution and community to work together to establish education system for patients with hypertension at the initial stage of diagnosis.
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