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Microscale Wireless Electrical Stimulators for Electroceutical Applications: a Review

김유리|임준영|이채은|송윤규
반도체설계교육센터 (IC DESIGN EDUCATION CENTER)|2022.07|IDEC Journal of Integrated Circuits and Systems|제8권 제3호|pp. 47-56|DOI 10.23075/jicas.2022.8.3.009

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키워드

Electrical stimulationDistributed microsystemElectroceuticalImplantable systemMicrostimulator

초록

Electroceutical has been used as an attractive approach to disease treatment, using electrical stimulation to modulate metabolic function and restore body homeostasis. As the first generation of electroceuticals, cardiac pacemakers and implantable defibrillators have saved countless lives over several decades. Due to the remarkable technological progress of implantable medical systems over the past few years, it has reached the point of transforming the existing system into a micro-scale system using semiconductor microelectronics. Herein, research trends regarding various disease applications of electroceuticals are reviewed. In particular, the components, specifications, and circuit structures of the stimulation sub-systems in electroceuticals are thoroughly analyzed.

Abstract

Electroceutical has been used as an attractive approach to disease treatment, using electrical stimulation to modulate metabolic function and restore body homeostasis. As the first generation of electroceuticals, cardiac pacemakers and implantable defibrillators have saved countless lives over several decades. Due to the remarkable technological progress of implantable medical systems over the past few years, it has reached the point of transforming the existing system into a micro-scale system using semiconductor microelectronics. Herein, research trends regarding various disease applications of electroceuticals are reviewed. In particular, the components, specifications, and circuit structures of the stimulation sub-systems in electroceuticals are thoroughly analyzed.

참고문헌 (59)

  1. G. Yao, "Effective weight control via an implanted self-powered vagus nerve stimulation device", Nat. Commun, 9(1), pp.1~10 (2018)[DOI]
  2. T. Izumi, "Vagus-macrophage-hepatocyte link promotes post-injury liver regeneration and whole-body survival through hepatic FoxM1 activation", Nat. Commun, 9(1), pp.1~13 (2018)[DOI]
  3. P. Chen, "Wireless electrical stimulation of the vagus nerves by ultrasound-responsive programmable hydrogel nanogenerators for anti-inflammatory therapy in sepsis", Nano Energy, 89(PA), pp.106327~ (2021)[DOI]
  4. I. T. Mughrabi, "Development and characterization of a chronic implant mouse model for vagus nerve stimulation", Elife, 10, pp.1~24 (2021)[DOI]
  5. R. H. Howland, "Vagus Nerve Stimulation", Curr. Behav. Neurosci. Reports, 1(2), pp.64~73 (2014)[DOI]
  6. H. Ulusan, "A Sub-500 μW Interface Electronics for Bionic Ears", IEEE Access, 7, pp.132140~132152 (2019)[DOI]
  7. E. With, "Fully Implantable Cochlear Implant Interface", 27(7), pp.1504~1512 (2019)
  8. E. Bloch, "Advances in retinal prosthesis systems", Ther. Adv. Ophthalmol, 11, pp.251584141881750~ (2019)[DOI]
  9. P. Gutruf, "Wireless, battery-free, fully implantable multimodal and multisite pacemakers for applications in small animal models", Nat. Commun, 10(1), pp.2019~ (2019)[DOI]
  10. M. S. Khan, "Design and Prototyping a Smart Deep Brain Stimulator: An Autonomous NeuroSensing and Stimulating Electrode System", IEEE Intell. Syst, 32(5), pp.14~27 (2017)[DOI]
  11. A. Priori, "Adaptive deep brain stimulation (aDBS) controlled by local field potential oscillations", Exp. Neurol, 245, pp.77~86 (2013)[DOI]
  12. F. A. Koopman, "Vagus nerve stimulation inhibits cytokine production and attenuates disease severity in Rheumatoid arthritis", Proc. Natl. Acad. Sci. U. S. A, 113(29), pp.8284~8289 (2016)[DOI]
  13. M. R. Gold, "Vagus Nerve Stimulation for the Treatment of Heart Failure: The INOVATE-HF Trial,", J. Am. Coll. Cardiol, 68(2), pp.149~115 (2016)[DOI]
  14. C. C. Horn, "Hydrogel-based electrodes for selective cervical vagus nerve stimulation", J. Neural Eng, 18(5), pp.2021~ (2021)[DOI]
  15. J. Y. Y. Yap, "Critical Review of Transcutaneous Vagus Nerve Stimulation: Challenges for Translation to Clinical Practice", Front. Neurosci, 14(April) (2020)[DOI]
  16. S. Washburn, "Patient-perceived differences between constant current and constant voltage spinal cord stimulation systems", Neuromodulation, 17(1), pp.28~36 (2014)[DOI]
  17. D. S. Kern, "Constant Current versus Constant Voltage: Clinical Evidence Supporting a Fundamental Difference in the Modalities", Stereotact. Funct. Neurosurg, 99(2), pp.171~175 (2021)[DOI]
  18. S. Ha, "A Fully Integrated RF-Powered EnergyReplenishing Current-Controlled Stimulator", IEEE Trans. Biomed. Circuits Syst, 13(1), pp.191~202 (2019)[DOI]
  19. S. Farahmand, "Wearable, battery-powered, wireless, programmable 8-channel neural stimulator", Proc. Annu. Int. Conf. IEEE Eng. Med. Biol. Soc. EMBS, 6120(6123), pp.6120~6123 (2012)[DOI]
  20. J. Liu, "A High-Voltage, Energy-Efficient, 4-Electrode Output Stage for Implantable Neural Stimulator", IEEE, (61006022), pp.762~765 (2015)
  21. W. Ngamkham, "Biphasic stimulator circuit for a wide range of electrode-tissue impedance dedicated to cochlear implants", ISCAS 2012 - 2012 IEEE Int. Symp. Circuits Syst, pp.1083~1086 (2012)
  22. 석창호, "A 16-channel Neural Stimulator IC with DAC Sharing Scheme for Artificial Retinal Prostheses", JOURNAL OF SEMICONDUCTOR TECHNOLOGY AND SCIENCE, 14(5), pp.658~665 (2014), 대한전자공학회
  23. R. Shulyzki, "320-channel active probe for highresolution neuromonitoring and responsive neurostimulation", IEEE Trans. Biomed. Circuits Syst, 9(1), pp.34~49 (2015)
  24. K. Abdelhalim, "CMOS DAC-sharing stimulator for neural recording and stimulation arrays", Proc. - IEEE Int. Symp. Circuits Syst, pp.1712~1715 (2011)
  25. D. Jiang, "A Multichannel HighFrequency Power-Isolated Neural Stimulator with Crosstalk Reduction", IEEE Trans. Biomed. Circuits Syst, 12(4), pp.940~953 (2018)[DOI]
  26. Y. Wu, "A MultiChannel Stimulator with High-Resolution Time-toCurrent Conversion for Vagal-Cardiac Neuromodulation", IEEE Trans. Biomed. Circuits Syst, 15(6), pp.1186~1195 (2021)[DOI]
  27. H. Kassiri, "An impedance-tracking battery-less arbitrarywaveform neurostimulator with load-adaptive 20V voltage compliance", Eur. Solid-State Circuits Conf, 2016-Octob, pp.225~228 (2016)[DOI]
  28. Z. Luo, "A High-Voltage-Tolerant and Power-Efficient Stimulator with Adaptive Power Supply Realized in Low-Voltage CMOS Process for Implantable Biomedical Applications", IEEE J. Emerg. Sel. Top. Circuits Syst, 8(2), pp.178~186 (2018)[DOI]
  29. Z. Luo, "A digitally dynamic power supply technique for 16-channel 12 V-tolerant stimulator realized in a 0.18-μm 1.8-V", 3.3-V low-voltage CMOS process, 2017, pp.11(5), 1087~1096
  30. D. Osipov, "Current driver with read-out HV protection for neural stimulation", NORCAS 2016 - 2nd IEEE NORCAS Conf (2016)
  31. C.-E. Le, "8-Channel Biphasic Current Stimulator Optimized for Retinal Prostheses", J. Nanosci. Nanotechnol, 21(8), pp.4298~4302 (2021)[DOI]
  32. D. Zhou, "Implantable Neural Prostheses 2: Techniques and Engineering Approaches" (2010)
  33. D. Osipov, "HV compliant current driver with onchip read-out protection switch for neural stimulation", Analog Integr. Circuits Signal Process, 92(3), pp.415~426 (2017)[DOI]
  34. X. Li, "16-Channel biphasic current-mode programmable charge balanced neural stimulation", Biomed. Eng. Online, 16(1), pp.104~ (2017)[DOI]
  35. E. Greenwald, "“A CMOS Current Steering Neurostimulation Array with Integrated DAC Calibration and Charge Balancing,", IEEE Trans. Biomed. Circuits Syst, 11(2), pp.324~335 (2017)[DOI]
  36. Y. J. Jeon, "A 0.034%Charge-Imbalanced Neural Stimulation Front-End (SFE)IC with on-Chip Voltage Compliance Monitoring Circuit and Analysis on Resting Potential by Utilizing the SFE IC", IEEE Trans. Circuits Syst. I Regul. Pap, 66(10), pp.3797~3810 (2019)[DOI]
  37. Y. Zhou, "A Closedloop Controlled Neural Stimulator with High Voltage Compliance in 0.18-μm Low Voltage CMOS Teachnology", 2019 IEEE Int. Conf. Integr. Circuits, Technol. Appl. ICTA 2019 - Proc, pp.158~159 (2019)
  38. R. Guan, "A Power-Efficient and Safe Neural Stimulator Using Ultra-High Frequency Current Pulses for Nerve Conduction Block", Proc. - APCCAS 2019 2019 IEEE Asia Pacific Conf. Circuits Syst. Innov. CAS Towar. Sustain. Energy Technol. Disrupt, pp.397~400 (2019)
  39. Y. K. Lo, "Precision control of pulse widths for charge balancing in functional electrical stimulation", Int. IEEE, 2013, 1481~1484
  40. W. Y. Hsu, "Compact, Energy-Efficient High-Frequency Switched Capacitor Neural Stimulator with Active Charge Balancing", IEEE Trans. Biomed. Circuits Syst, 11(4), pp.878~888 (2017)[DOI]
  41. H. Pu, "A 40V voltage-compliance 12.75 mA maximum-current multipolar neural stimulator using time-based charge balancing technique achieving 2mV precision", IEEE Custom Integrated Circuits Conference (CICC), pp.3~4 (2021)
  42. R. Ranjandish, "A design methodology for charge-balanced stimulators based on anodic current variation monitoring", Analog Integr. Circuits Signal Process, 101(2), pp.341~350 (2019)[DOI]
  43. K. Zheng, "Design of a Biphasic Current-Matching Neural Stimulator", Proc. Int. Conf. Anti-Counterfeiting, Secur. Identification, 2019, pp.286~290 (2019)
  44. G. O’Leary, "NURIP: Neural Interface Processor for Brain-State Classification and ProgrammableWaveform Neurostimulation", IEEE J. Solid-State Circuits, 53(11), pp.3150~3162 (2018)[DOI]
  45. C. C. Hsieh, "Monopolar Biphasic Stimulator with Discharge Function and Negative Level Shifter for Neuromodulation SoC Integration in LowVoltage CMOS Process", IEEE Trans. Biomed. Circuits Syst, 15(3), pp.568~579 (2021)[DOI]
  46. J. Y. Son, "An Implantable Neural Stimulator IC with Anodic Current Pulse Modulation Based Active Charge Balancing", IEEE Access, 8, pp.136449~136458 (2020)[DOI]
  47. B. Lee, "An Inductively-Powered Wireless Neural Recording and Stimulation System for Freely-Behaving Animals", IEEE Trans. Biomed. Circuits Syst, 13(2), pp.413~424 (2019)[DOI]
  48. S. Shahdoost, "Generation of Stimulus Triggering From Intracortical Spike Activity for Brain-Machine-Body Interfaces (BMBIs)", IEEE Trans. Neural Syst. Rehabil. Eng, 25(7), pp.998~1008 (2017)[DOI]
  49. S. S. Ghoreishizadeh, "Four-Wire Interface ASIC for a Multi-Implant Link", IEEE Trans. Circuits Syst. I Regul. Pap, 64(12), pp.3056~3067 (2017)
  50. A. H. Lee, "Wireless Addressable Cortical Microstimulators Powered by Near-Infrared Harvesting", ACS Sensors, 6(7), pp.2728~2737 (2021)[DOI]
  51. M. Daneshzand, "Robust desynchronization of Parkinson’s disease pathological oscillations by frequency modulation of delayed feedback deep brain stimulation", PLoS One, 13(11), pp.1~22 (2018)[DOI]
  52. D. Seo, "Wireless Recording in the Peripheral Nervous System with Ultrasonic Neural Dust,", Neuron, 91(3), pp.529~539 (2016)[DOI]
  53. B. C. Johnson, "StimDust: A 6.5mm3, wireless ultrasonic peripheral nerve stimulator with 82% peak chip efficiency", IEEE Custom Integrated Circuits Conference, 2018, pp.1~4 (2018)
  54. A. Khalifa, "The Microbead: A Highly Miniaturized Wirelessly Powered Implantable Neural Stimulating System", IEEE Trans. Biomed. Circuits Syst, 12(3), pp.521~531 (2018)[DOI]
  55. F. Laiwalla, "A Distributed Wireless Network of Implantable Sub-mm Cortical Microstimulators for Brain-Computer Interfaces", Proc. Annu. Int. Conf. IEEE Eng. Med. Biol. Soc. EMBS, pp.6876~6879 (2019)
  56. J. Lee, "Neural recording and stimulation using wireless networks of microimplants", Nat. Electron, 4(8), pp.604~614 (2021)[DOI]
  57. J. Charthad, "A mm-Sized wireless implantable device for electrical stimulation of peripheral nerves", IEEE Trans. Biomed. Circuits Syst, 12(2), pp.257~270 (2018)[DOI]
  58. "Neural Dust: An Ultrasonic, Low Power Solution for Chronic Brain-Machine Interfaces" (2013)[URL]
  59. Z. Yu, "MagNI: A Magnetoelectrically Powered and Controlled Wireless Neurostimulating Implant", IEEE Trans. Biomed. Circuits Syst, 14(6), pp.1241~1252 (2020)[DOI]

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