혈청 표지자 분석을 통한 근위 대퇴 골절 형태 예측
Prediction of Type of Proximal Femur Fracture by Analysis of Serum Makers
1
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Purpose: To analyze serum markers in proximal femur fracture patients, which are known to be accompanied with osteophorosis or metabolic diseases, and consider it as predictive factor and to study how it affects on the fracture form. Materials and Methods: Vit. D3 known as serum marker of Vit. D, 25(OH)D, and 1,25(OH)2D of 152 patients from April, 2013 to March, 2014 who visited our hospital and diagnosed as proximal femur fracture(Femur neck fracture 73, Intertrochanteric fracture 79) were analyzed. Also, serum calcium level corrected by serum protein, phosphate, creatinine, alkaline phosphatase, estradiol, IGF-1, and PTH were compared and analyzed. Results: Femur neck fracture group showed significantly low value of D3, 25(OH)D, and 1,25(OH)2D (P-value<0.05) as the values were 37.72±7.21 pg/mL, 27.05±8.43 ng/mL, 25.05±6.78 pg/mL in femur neck fracture group, and 40.36±6.97 pg/mL, 29.54±9.12 ng/mL, 28.87±7.43 pg/mL in intertrochanteric fracture group respectively. The number of patients who were diagnosed as hypovitaminosis D. due to serum 25(OH)D value lower than 30ng/ml were significantly high in femur neck fracture group as the numbers were 56 in femur neck fracture, and 44 in intertrochanteric fracture. Serum calcium level corrected by serum protein, phosphate, creatinine, alkaline phosphatase, estradiol, IGF-1 and PTH level showed no significant difference between two groups. Conclusion: Serum 25(OH)D level was decreased in proximal femur fracture patiens, and was lower as the patient was older and BMD was lower. Therefore it is thought that proximal femur fracture is affected by vitamin D metabolism.
Abstract
Purpose: To analyze serum markers in proximal femur fracture patients, which are known to be accompanied with osteophorosis or metabolic diseases, and consider it as predictive factor and to study how it affects on the fracture form. Materials and Methods: Vit. D3 known as serum marker of Vit. D, 25(OH)D, and 1,25(OH)2D of 152 patients from April, 2013 to March, 2014 who visited our hospital and diagnosed as proximal femur fracture(Femur neck fracture 73, Intertrochanteric fracture 79) were analyzed. Also, serum calcium level corrected by serum protein, phosphate, creatinine, alkaline phosphatase, estradiol, IGF-1, and PTH were compared and analyzed. Results: Femur neck fracture group showed significantly low value of D3, 25(OH)D, and 1,25(OH)2D (P-value<0.05) as the values were 37.72±7.21 pg/mL, 27.05±8.43 ng/mL, 25.05±6.78 pg/mL in femur neck fracture group, and 40.36±6.97 pg/mL, 29.54±9.12 ng/mL, 28.87±7.43 pg/mL in intertrochanteric fracture group respectively. The number of patients who were diagnosed as hypovitaminosis D. due to serum 25(OH)D value lower than 30ng/ml were significantly high in femur neck fracture group as the numbers were 56 in femur neck fracture, and 44 in intertrochanteric fracture. Serum calcium level corrected by serum protein, phosphate, creatinine, alkaline phosphatase, estradiol, IGF-1 and PTH level showed no significant difference between two groups. Conclusion: Serum 25(OH)D level was decreased in proximal femur fracture patiens, and was lower as the patient was older and BMD was lower. Therefore it is thought that proximal femur fracture is affected by vitamin D metabolism.
참고문헌 (17)
- Boonen S, "Functional outcome and quality of life following hip fracture in elderly women: a prospective controlled study", Osteoporosis Int, 15, pp.87~94 (2004)
- Davidson CW, "Hip fracture mortality and morbidity--can we do better?", N Z Med J, 114, pp.329~332 (2001)
- 이성락, "고관절 주위골절로 인한 사망률 및 활동성 -전향적 연구-", 대한정형외과학회지, 40(4), pp.423~427 (2005), 대한정형외과학회
- Magaziner J, "Excess mortality attributable to hip fracture in white women aged 70 years and older", Am J Public Health, 87, pp.1630~1636 (1997)
- Sambrook P, "Osteoporosis", Lancet, 367, pp.2010~2018 (2006)
- Cummings SR, "The future of hip fractures in the United States. Numbers, costs and potential effects of postmenopausal estrogen", Clin Orthop Relat Res, 252, pp.163~166 (1990)
- Melton LJ 3rd, "Osteoporosis and the risk of hip fracture", Am J Epidemiol, 124, pp.254~261 (1986)
- Schott AM, "How hip and whole-body bone mineral density predict hip fracture in elderly women: the EPIDOS Prospective Study", Osteoporos Int, 8, pp.247~254 (1998)
- Moniz C, "Prevalence of vitamin D inadequacy in osteoporotic hip fracture patients in London", Curr Med Res Opin, 21, pp.1891~1894 (2005)
- 이원석, "골다공증성고관절 골절 환자에서의 비타민 D 결핍", 대한골대사학회지, 18(1), pp.9~14 (2011), 대한골대사학회
- Kuchuk NO, "Relationships of Serum 25-Hydroxyvitamin D to Bone Mineral Density and Serum Parathyroid Hormone and Markers of Bone Turnover in Older Persons", J Clin Endocrinol Metab, 94, pp.1244~1250 (2009)
- Barrett-Connor E, "Gender differences in insulin-like growth factor and bone mineral density association in old age: the Rancho Bernardo Study", J Bone Miner Res, 13, pp.1343~1349 (1998)
- Janssen JA, "Gender-specific relationship between serum free and total IGF-I and bone mineral density in elderly men and women", Eur J Endocrinol, 138, pp.627~632 (1998)
- Garnero P, "Low serum IGF-1 and occurrence of osteoporotic fractures in postmenopausal women", Lancet, 355(9207), pp.898~899 (2000)
- Ohlsson C, "Older men with low serum IGF-1 have an increased risk of incident fractures: the MrOS Sweden study", J Bone Miner Res, 26, pp.865~872 (2011)
- Bennett AE, "Insulin-like growth factors I and II: aging and bone density in women", J Clin Endocrinol Metab, 59, pp.701~704 (1984)
- Bogunovic L, "Hypovitaminosis D in Patients Scheduled to Undergo Orthopaedic Surgery: A Single-Center Analysis", J Bone Joint Surg Am, 92, pp.2300~2304 (2010)