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제조나노물질의 안전성 평가를 위한 시료준비 및 물리화학적 특성분석 기법

Sample Preparation and Analysis of Physico-Chemical Properties for Safety Assessment of Manufactured Nanomaterials

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Abstract

Manufactured nanomaterials have drawn attention due to their potential toxic effects on human and environment. The physico-chemical properties of nanomaterials can play an important role on the understanding of the toxicity mechanism, however, few physico-chemical properties have been reported. Nanomaterials can be dispersed by the solvent-exchange method, the water-stirring method or the washing method. Importantly, the sample of nanomaterials for the toxicity evaluation should not contain any other chemicals, such as the solvent and catalysts. In addition, the physico-chemical properties, including size, agglomeration, solubility, crystalline structure, surface area, density, octanol-water partition coefficient, dustiness, surface composition, surface charge, surface energy, surface reactivity, photocatalytic activity, redox potential or the radical formation potential should be characterized during the sample preparation and toxicity evaluation. These physicochemical properties should be correlated with the extent of toxicity.

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