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약물 방출 시스템으로서 이부프로펜/클레이 유-무기 나노복합체의 층간삽입 거동 연구

Intercalation behavior study of ibuprofen/clay organic-inorganic nanocomposites as drug release system

김동현|김태완|윤석영|박홍채|진형호|최봉석
한국결정성장학회 (The Korea Association Of Crystal Growth, Inc.)|2011.12|한국결정성장학회지 (Journal of the Korean Crystal Growth and Crystal Technology)|제21권 제6호|pp. 240-245

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참고문헌

키워드

NanocompositesClayIntercalationIbuprofen
주제분류재료공학

초록

본 연구는 지속적 약물방출 전달체로서의 클레이 내의 재결정화 된 이부프로펜 층간삽입 거동에 대해 주안점을두었다. 이부프로펜의 층간삽입 거동은 X-선 회절 및 열 중량 분석을 통해 확인하였다. 클레이의 기저 공간은 이부프로펜분자에 의해 1.2 nm에서 1.5 nm까지 증가하였다. 또한 클레이 내부 공간 층에 존재하는 이부프로펜의 부분 운동은 이부프로펜/클레이 나노복합체의 열적 안정성을 증가시켰다. 나노복합체의 in vitro 약물방출 결과는 이부프로펜이 클레이로부터일정하게 방출됨을 보였다.

Abstract

This research focused on the intercalation behavior of recrystallized ibuprofen into clay as a sustained release drug carrier. The intercalation behaviors of ibuprofen were determined by X-ray diffraction (XRD) and thermogravimetric analysis (TGA). The basal spacing (d001) of clay increased from 1.2 nm to 1.5 nm by ibuprofen molecules. The segmental motion effect of ibuprofen into the clay interlayer spacing also increased the thermal stability of the ibuprofen/clay nanocomposites. The in vitro drug release results of nanocomposites showed that ibuprofen was released from clay steadily.

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