흡수성 치주조직 재생 차폐막에 대한 비교연구
Comparative study on absorbable periodontal tissue regeneration barrier membranes
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초록
흡수성 치주조직 재생유도재(국내 4개, 국외 2개) 총 6개 제품을 비교 연구하였다. 이종소재 차폐막의 경우, 콜라겐 제품은 우수한 기계적 강도를 보였으나 연신율이 작았다. 돼지심막은 우수한 기계적 물성에도 불구하고 두꺼운 두께로 사용에 제약이 되었다. 전기방사법으로 제조한 독일 PLLA/콜라겐 하이브리드형 복합 차폐막은 강도값과 흡수도는 낮았지만, 합성 및 천연고분자를 적절히 혼합함으로써 원하는 특성의 기계적 물성과 생체적합성 구현이 가능하였다. 본 연구에서 DA02(PLLA/젤라틴) 하이브리드형 복합고분자 소재는 기계적 물성과 생체적합성이 적절하여 100% 수입에 의존하는 하이브리드형 흡수성 치주조직 재생 차폐막에 적용이 가능하였다.
Abstract
Absorbable periodontal tissue regeneration barrier membranes (total 6; domestic 4; import 2) were comparatively analyzed. In the case of the xenograft barrier membrane, the collagen product had excellent tensile strength but low strain,and the porcine pericardial membrane had good mechanical properties, but its thickness was too thick to control. The synthetic PLLA membrane manufactured by the electrospinning had a relatively low water absorption capacity. However,the hybrid barrier membrane was able to control mechanical properties and biocompatibility through proper mixing of synthetic polymer and natural polymer. DA02 (PLLA/gelatin), a newly developed hybrid absorbable periodontal tissueregeneration membrane that is entirely dependent on imports, can be applied to an absorbable periodontal tissue regeneration barrier membrane due to suitable mechanical properties and biocompatibility.
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