Effect of Transcranial Direct Current Stimulation on Motor Function in Patients With Stroke: A Meta-Analysis of Randomized Controlled Trials
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Objective: The study aim was to assess the effect of transcranial direct current stimulation (tDCS) on motor function enhancement in patients with stroke through a meta-analysis of randomized controlled trials. Methods: We searched the PubMed and Scopus databases for relevant randomized controlled trials published before February 2023. The methodological quality of the included studies was evaluated using the Physiotherapy Evidence Database (PEDro) scale. Fourteen studies were included in this meta-analysis. Results: The overall effect size was 0.370 (95% CI [0.268, 0.472], p < .05), indicating a small but significant improvement in motor function after tDCS. For activities of daily living (ADL), the effect size was 0.340 (95% CI [−0.099, 0.778], p > .05), indicating a nonsignificant impact. Lower limb motor function had an effect size of 0.171 (95% CI [−0.047, 0.390], p > .05), also nonsignificant. However, upper limb motor function showed a significant effect size of 0.431 (95% CI [0.312, 0.551], p < .05), indicating a significant improvement following tDCS. Conclusion: These results provide evidence that tDCS improved motor function in patients with stroke, particularly in the upper limbs. These findings support its potential role as a therapeutic intervention in stroke rehabilitation.
Abstract
Objective: The study aim was to assess the effect of transcranial direct current stimulation (tDCS) on motor function enhancement in patients with stroke through a meta-analysis of randomized controlled trials. Methods: We searched the PubMed and Scopus databases for relevant randomized controlled trials published before February 2023. The methodological quality of the included studies was evaluated using the Physiotherapy Evidence Database (PEDro) scale. Fourteen studies were included in this meta-analysis. Results: The overall effect size was 0.370 (95% CI [0.268, 0.472], p < .05), indicating a small but significant improvement in motor function after tDCS. For activities of daily living (ADL), the effect size was 0.340 (95% CI [−0.099, 0.778], p > .05), indicating a nonsignificant impact. Lower limb motor function had an effect size of 0.171 (95% CI [−0.047, 0.390], p > .05), also nonsignificant. However, upper limb motor function showed a significant effect size of 0.431 (95% CI [0.312, 0.551], p < .05), indicating a significant improvement following tDCS. Conclusion: These results provide evidence that tDCS improved motor function in patients with stroke, particularly in the upper limbs. These findings support its potential role as a therapeutic intervention in stroke rehabilitation.