표적 기억 재활성화로 수면 중 기억 강화 증진 시키기
Targeted Memory Reactivation can Enhance Memory Consolidation during Sleep
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초록
TMR은 이전 학습 과제와 연관되었던 단서 자극을 사용하여 현재 학습의 재활성화를 유도하는 절차적 방법을 일컫는다. 여러 동물 및 인간 연구들에서 TMR이 수면 중 기억강화를 증진하는 유용한 방법이라는 것이 증명되었고 특히서술 기억 영역에 일관된 결과를 보인다. 청각 혹은 후각 단서 자극을 은밀히 제시하는 방법을 적용한 수면 중 신경인지 처리 과정을 통하여 기억 강화의 증진을 도모할 수 있었다. 이러한 증진 효과는 기억 강화와 관련된 뇌 부위의 활성과 연관되어있다. 이 종설을 통하여 TMR을 적용한 수면 중기억 강화 연구들의 현황을 살펴보았고 다양한 분야에서의발전 가능성을 엿볼 수 있었다.
Abstract
Targeted memory reactivation (TMR) is a method whereby cues associated with previous learning are used to externally reactivate aspects of this learning. Research findings demonstrate that TMR can be a useful tool to enhance memory consolidation during sleep in both animals and humans, especially in the declarative/spatial domain. Neurocognitive processing during sleep with covert cueing via auditory or olfactory stimulation can benefit memory storage. These beneficial effects on memory consolidation during sleep are associated with the activation of memory-related brain areas. The purpose of the present review is to provide a short overview of the findings of studies that adopted the TMR method of sleep-dependent memory consolidation and to suggest the potential applications of TMR in variable areas.
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