감기 후 후각상실(Post-Viral Olfactory Dysfunction) 환자에서 한의학적 복합 치료의 임상적 유효성: 증례 보고

Abstract

Abstract Post-viral olfactory dysfunction (PVOD) is a common form of sensorineural olfactory loss that occurs following upper respiratory infections. It results from damage or inflammation of the olfactory epithelium caused by viral infection, leading to temporary or persistent loss of smell. Conventional treatments such as corticosteroids or vitamin supplementation often show limited efficacy. This case report presents the clinical improvement of a 52-year-old male patient who developed anosmia after a common cold and was treated with Korean medicine combination therapy. The treatment included herbal medication (Yukmijihwang-tang with modifications), acupuncture, pharmacopuncture with Hwangryunhaedok-tang extract, and olfactory training using essential oils. Olfactory function was evaluated using the Connecticut Chemosensory Clinical Research Center (CCCRC) Test. The total score improved from 3 (severe dysfunction) at baseline to 17 (normal range) after four months of treatment. The patient’s sense of smell and taste were fully restored, with resolution of associated anxiety and insomnia. This case suggests that Korean medicine combination therapy may promote neural recovery and improve olfactory function in PVOD by enhancing neurotrophic activity, particularly through ingredients known to increase brain-derived neurotrophic factor (BDNF). Further controlled clinical studies are needed to verify its therapeutic potential and mechanism of action.