볼거리 고환염의 발생 양상 및 계절별 빈도 분석: 한국의 다기관연구
Outbreaks and Seasonal Variation of Mumps Orchitis: Report of Multicenter Data in Korea
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Purpose: Mumps is an infectious viral disease that often results in painful swelling of testis preceded by parotitis. We report multicenter data on mumps orchitis from five community hospitals. Materials and Methods: From January 2011 to December 2012, 98 patients diagnosed with acute mumps orchitis were treated at five community hospitals in different districts of Korea. As a report on an outbreak of mumps orchitis, age, bilaterality, monthly occurrence frequency, and vaccination status were recorded retrospectively. Results: The mean age of the 98 patients was 19.7 (range from 10 to 38) years old. Age distribution of patients included 60 teens (61.2%), 31 in their twenties (31.6%), and seven in their thirties (7.2%). No evidence of a previous mumps vaccination was found in medical records from six patients (6.1%), and the vaccination status of one patient was unknown. Bilateral orchitis was noted in eight patients (8.2%), and 90 patients (91.8%) had unilateral orchitis. Right-sided orchitis was noted in 50 patients (51.0%), and left-sided orchitis was noted in 40 patients (40.8%). Autumn (September to November) was the most prevalent season, with 35 outbreaks (35.7%). Seasonal outbreaks occurred in 13 patients (13.2%) in spring (3rd- 5th), 24 patients (24.7%) in summer (6th-8th), and 26 patients (26.4%) in winter (12th-2nd). Conclusions: In spite of continued vaccination, mumps orchitis is still a prevalent disease. Therefore, due to a large number of outbreaks, mumps orchitis should still be considered, especially in teenagers and during autumn season. Conduct of additional long-term follow-up and large prospective studies is needed in Korea.
Abstract
Purpose: Mumps is an infectious viral disease that often results in painful swelling of testis preceded by parotitis. We report multicenter data on mumps orchitis from five community hospitals. Materials and Methods: From January 2011 to December 2012, 98 patients diagnosed with acute mumps orchitis were treated at five community hospitals in different districts of Korea. As a report on an outbreak of mumps orchitis, age, bilaterality, monthly occurrence frequency, and vaccination status were recorded retrospectively. Results: The mean age of the 98 patients was 19.7 (range from 10 to 38) years old. Age distribution of patients included 60 teens (61.2%), 31 in their twenties (31.6%), and seven in their thirties (7.2%). No evidence of a previous mumps vaccination was found in medical records from six patients (6.1%), and the vaccination status of one patient was unknown. Bilateral orchitis was noted in eight patients (8.2%), and 90 patients (91.8%) had unilateral orchitis. Right-sided orchitis was noted in 50 patients (51.0%), and left-sided orchitis was noted in 40 patients (40.8%). Autumn (September to November) was the most prevalent season, with 35 outbreaks (35.7%). Seasonal outbreaks occurred in 13 patients (13.2%) in spring (3rd- 5th), 24 patients (24.7%) in summer (6th-8th), and 26 patients (26.4%) in winter (12th-2nd). Conclusions: In spite of continued vaccination, mumps orchitis is still a prevalent disease. Therefore, due to a large number of outbreaks, mumps orchitis should still be considered, especially in teenagers and during autumn season. Conduct of additional long-term follow-up and large prospective studies is needed in Korea.
참고문헌 (16)
- Yvonne M, "Mumps, In Nelson textbook of pediatrics", pp.1035~1036 (2004), Saunders
- Muhlemann K., "The molecular epidemiology of mumps virus", Infect Genet Evol, 4, pp.215~219 (2004)
- Baum SG, "Mumps virus, In Principle and practice of infectious disease", pp.1260~1264 (1990), Churchill Livingstone
- Choi YM, "Measle, mumps, rubella (MMR) vaccination: guide to vaccinations", pp.48~54 (1992), Jungmoonsa Inc.
- Davis NF, "The increasing incidence of mumps orchitis: a comprehensive review", BJU Int, 105, pp.1060~1065 (2010)
- Hviid A, "Mumps", Lancet, 371, pp.932~944 (2008)
- Kim DH, "Effects of systemic treatment with interferon-alpha2b for mumps orchitis", Korean J Urol, 36, pp.963~968 (1995)
- Yeniyol CO, "Role of interferon- alpha-2B in prevention of testicular atrophy with unilateral mumps orchitis", Urology, 55, pp.931~933 (2000)
- Centers for Disease Control and Prevention (CDC), "Mumps outbreak - New York, New Jersey, Quebec, 2009", MMWR Morb Mortal Wkly Rep, 58, pp.1270~1274 (2009)
- 이진수, "MMR 백신 부작용 발생 실태 - 보건소 전화 조사를 통한 전향적 연구 -", Pediatric Infection and Vaccine, 7(2), pp.183~192 (2000), 대한소아감염학회
- Kang HD, "An outbreak of mumps in Taejon, Korea, 1998", Korean J Pediatr Infect Dis, 11, pp.239~244 (1999)
- School based infectious disease surveillance report, "Korean Center for Disease Control and Prevention", Korea Center for Disease Control and Prevention, ~
- Korea Center for Disease Control & Prevention, "2004 Communicable diseases statistical yearbook" (2005), Korea Center for Disease Control & Prevention
- Berman S, "Epidemiology of acute respiratory infections in children of developing countries", Rev Infect Dis, 13(Suppl 6), pp.S454~462 (1991)
- Leland DS, "Manual of clinical microbiology", pp.1352~1360 (2007), ASM Press
- 이혜진, "2008-2011년 서울 및 경기지역의 파라인플루엔자 바이러스 감염의 역학적 특성", Annals of Clinical Microbiology, 15(2), pp.54~59 (2012), 대한임상미생물학회