The Association between Chronic Inflammation and Recurrent Cystitis in Women
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Recurrent urinary tract infection is a common infectious disease seen in the clinic. It is very prevalent in women; as many as 15% of women develop urinary tract infection each year, and at least 25% have one or more recurrences. Chronic inflammation and increased urothelial apoptosis reflect a common patho-physiology in various lower urinary tract dysfunctions, causing bladder storage symptoms. It has been suggested that chronic inflammation could be associated with overactive detrusor and increased levels of urinary nerve growth factor and creatinine. The level of urinary nerve growth factor may decrease after an effective antimuscarinic therapy. Recurrent urinary tract infection could be prevented by using nonsteroidal anti-inflammatory drugs or cyclooxygenase-2 inhibitors. Intravesical hyaluronate and chondroitin sulfate reduce the incidence of recurrent bacterial cystitis, and treatment with hyaluronate targets bacterial adherence to the bladder mucosa in interstitial cystitis/bladder pain syndrome. This article reviews the pathophysiology of chronic inflammation of the bladder and investigates the association between chronic inflammation and recurrent urinary tract infection.
Abstract
Recurrent urinary tract infection is a common infectious disease seen in the clinic. It is very prevalent in women; as many as 15% of women develop urinary tract infection each year, and at least 25% have one or more recurrences. Chronic inflammation and increased urothelial apoptosis reflect a common patho-physiology in various lower urinary tract dysfunctions, causing bladder storage symptoms. It has been suggested that chronic inflammation could be associated with overactive detrusor and increased levels of urinary nerve growth factor and creatinine. The level of urinary nerve growth factor may decrease after an effective antimuscarinic therapy. Recurrent urinary tract infection could be prevented by using nonsteroidal anti-inflammatory drugs or cyclooxygenase-2 inhibitors. Intravesical hyaluronate and chondroitin sulfate reduce the incidence of recurrent bacterial cystitis, and treatment with hyaluronate targets bacterial adherence to the bladder mucosa in interstitial cystitis/bladder pain syndrome. This article reviews the pathophysiology of chronic inflammation of the bladder and investigates the association between chronic inflammation and recurrent urinary tract infection.
참고문헌 (58)
- 최현섭, "National Trends of Antimicrobial Resistance in Uncomplicated Cystitis", Urogenital Tract Infection, 11(1), pp.7~11 (2016), 대한요로생식기감염학회
- Grover S, "Role of inflammation in bladder function and interstitial cystitis", Ther Adv Urol, 3, pp.19~33 (2011)
- Liu HT, "Alteration of urothelial Inflammation, apoptosis, and junction protein in patients with various bladder conditions and storage bladder symptoms suggest common pathway involved in underlying pathophysiology", Low Urin Tract Symptoms, 7, pp.102~107 (2015)
- Liu HT, "Increased serum adipokines implicate chronic inflammation in the pathogenesis of overactive bladder syndrome refractory to antimuscarinic therapy", PLoS One, 8, pp.e76706~ (2013)
- Tyagi P, "Urine cytokines suggest an inflammatory response in the overactive bladder : a pilot study", Int Urol Nephrol, 42, pp.629~635 (2010)
- Hooton TM, "Fluoroquinolones and resistance in the treatment of uncomplicated urinary tract infection", Int J Antimicrob Agents, 22(Suppl 2), pp.65~72 (2003)
- Fihn SD, "Clinical practice. Acute uncomplicated urinary tract infection in women", N Engl J Med, 349, pp.259~266 (2003)
- Foxman B, "Urinary tract infection : self-reported incidence and associated costs", Ann Epidemiol, 10, pp.509~515 (2000)
- Car J, "Urinary tract infections in women : diagnosis and management in primary care", BMJ, 332, pp.94~97 (2006)
- Foxman B, "Epidemiology of urinary tract infections: incidence, morbidity, and economic costs", Am J Med, 113(Suppl 1A), pp.5S~13S (2002)
- Foxman B., "Epidemiology of urinary tract infections: incidence, morbidity, and economic costs", Dis Mon, 49, pp.53~70 (2003)
- Foxman B, "The epidemiology of urinary tract infection", Nat Rev Urol, 7, pp.653~660 (2010)
- Arya LA, "Evidence of bladder oversensitivity in the absence of an infection in premenopausal women with a history of recurrent urinary tract infections", BJU Int, 110, pp.247~251 (2012)
- Birder L, "Urothelial signaling", Physiol Rev, 93, pp.653~680 (2013)
- Liu HT, "Urinary nerve growth factor levels are elevated in patients with detrusor overactivity and decreased in responders to detrusor botulinum toxin-A injection", Eur Urol, 56, pp.700~706 (2009)
- Liu HT, "Urinary nerve growth factor levels in overactive bladder syndrome and lower urinary tract disorders", J Formos Med Assoc, 109, pp.862~878 (2010)
- Chan CY, "Mast cell interleukin-10drives localized tolerance in chronic bladder infection", Immunity, 38, pp.349~359 (2013)
- Ratner JJ, "Bacteria-specific antibody in the urine of patients with acute pyelonephritis and cystitis", J Infect Dis, 143, pp.404~412 (1981)
- Rene P, "Serological response to Escherichia coli pili in pyelonephritis", Infect Immun, 37, pp.749~754 (1982)
- Sant GR, "The mast cell in interstitial cystitis: role in pathophysiology and pathogenesis", Urology, 69(4 Suppl), pp.34~40 (2007)
- Khasriya R, "Spectrum of bacterial colonization associated with urothelial cells from patients with chronic lower urinary tract symptoms", J Clin Microbiol, 51, pp.2054~2062 (2013)
- Sorrentino F, "Associations between individual lower urinary tract symptoms and bacteriuria in random urine samples in women", Neurourol Urodyn, 34, pp.429~433 (2015)
- Balachandran AA, "Is chronic urinary infection a cause of overactive bladder?", Eur J Obstet Gynecol Reprod Biol, 201, pp.108~112 (2016)
- Hannan TJ, "Inhibition of cyclooxygenase-2 prevents chronic and recurrent cystitis", EBioMedicine, 1, pp.46~57 (2014)
- Hannan TJ, "Early severe inflammatory responses to uropathogenic E. coli predispose to chronic and recurrent urinary tract infection", PLoS Pathog, 6, pp.e1001042~ (2010)
- Schlager TA, "B cell infiltration and lymphonodular hyperplasia in bladder submucosa of patients with persistent bacteriuria and recurrent urinary tract infections", J Urol, 186, pp.2359~2364 (2011)
- Jang J, "Effects of intravesical instillation of cyclooxygenase-2 inhibitor on the expression of inducible nitric oxide synthase and nerve growth factor in cyclophosphamide-induced overactive bladder", BJU Int, 98, pp.435~439 (2006)
- Vizzard MA, "Changes in urinary bladder neurotrophic factor mRNA and NGF protein following urinary bladder dysfunction", Exp Neurol, 161, pp.273~284 (2000)
- Yoshimura N, "Bladder afferent pathway and spinal cord injury : possible mechanisms inducing hyperreflexia of the urinary bladder", Prog Neurobiol, 57, pp.583~606 (1999)
- Liu HT, "Urinary nerve growth factor levels are increased in patients with bladder outlet obstruction with overactive bladder symptoms and reduced after successful medical treatment", Urology, 72, pp.104~108 (2008)
- Lowe EM, "Increased nerve growth factor levels in the urinary bladder of women with idiopathic sensory urgency and interstitial cystitis", Br J Urol, 79, pp.572~577 (1997)
- Liu HT, "Urinary nerve growth factor level could be a potential biomarker for diagnosis of overactive bladder", J Urol, 179, pp.2270~2274 (2008)
- Liu HT, "Urinary nerve growth factor level could be a biomarker in the differential diagnosis of mixed urinary incontinence in women", BJU Int, 102, pp.1440~1444 (2008)
- Kuo HC, "Urinary nerve growth factor levels in urinary tract diseases with or without frequency urgency symptoms", Low Urin Tract Symptoms, 2, pp.88~94 (2010)
- Gupta K, "Management of urinary tract infections from multidrug-resistant organisms", Infect Dis Clin North Am, 28, pp.49~59 (2014)
- Ikäheimo R, "Recurrence of urinary tract infection in a primary care setting : analysis of a 1-year follow-up of 179women", Clin Infect Dis, 22, pp.91~99 (1996)
- Mysorekar IU, "Mechanisms of uropathogenic Escherichia coli persistence and eradication from the urinary tract", Proc Natl Acad Sci U S A, 103, pp.14170~14175 (2006)
- Mulvey MA, "Establishment of a persistent Escherichia coli reservoir during the acute phase of a bladder infection", Infect Immun, 69, pp.4572~4579 (2001)
- Poggi MM, "Glycosaminoglycan content of human bladders : a method of analysis using cold-cup biopsies", Urol Oncol, 5, pp.234~237 (2000)
- Constantinides C, "Prevention of recurrent bacterial cystitis by intravesical administration of hyaluronic acid : a pilot study", BJU Int, 93, pp.1262~1266 (2004)
- Stav K, "Interstitial cystitis", painful bladder syndrome : a comprehensive review of the current literature, 2011, pp.150, 168~174
- Hurst RE, "Functional and structural characteristics of the glycosaminoglycans of the bladder luminal surface", J Urol, 138, pp.433~437 (1987)
- Raymond I, "The clinical effectiveness of intravesical sodium hyaluronate(cystistatⓇ)in patients with interstitial cystitis", painful bladder syndrome and recurrent urinary tract infections, 2012, pp.6, 93~98
- De Vita D, "Effectiveness of intravesical hyaluronic acid", chondroitin sulfate in recurrent bacterial cystitis : a randomized study, 2012, pp.23, 1707~1713
- Damiano R, "Prevention of recurrent urinary tract infections by intravesical administration of hyaluronic acid and chondroitin sulphate : a placebo-controlled randomised trial", Eur Urol, 59, pp.645~651 (2011)
- Amdekar S, "Probiotic therapy : immunomodulating approach toward urinary tract infection", Curr Microbiol, 63, pp.484~490 (2011)
- Stapleton AE, "Randomized, placebo-controlled phase 2trial of a Lactobacillus crispatus probiotic given intravaginally for prevention of recurrent urinary tract infection", Clin Infect Dis, 52, pp.1212~1217 (2011)
- Jepson RG, "Cranberries for preventing urinary tract infections", Cochrane Database Syst Rev, (1), pp.CD001321~ (2008)
- Schwenger EM, "Probiotics for preventing urinary tract infections in adults and children", Cochrane Database Syst Rev, (12), pp.CD008772~ (2015)
- Jepson RG, "Cranberries for preventing urinary tract infections", Cochrane Database Syst Rev, 10, pp.CD001321~ (2012)
- Takahashi S, "A randomized clinical trial to evaluate the preventive effect of cranberry juice(UR65)for patients with recurrent urinary tract infection", J Infect Chemother, 19, pp.112~117 (2013)
- Jepson R, "Cranberry products and prevention of urinary tract infections", JAMA, 310, pp.1395~1396 (2013)
- Schmidhammer S, "An Escherichia coli-based oral vaccine against urinary tract infections potently activates human dendritic cells", Urology, 60, pp.521~526 (2002)
- Bauer HW, "A long-term, multicenter, double-blind study of an Escherichia coli extract (OM-89) in female patients with recurrent urinary tract infections", Eur Urol, 47, pp.542~548 (2005)
- Tammen H, "Immunobiotherapy with Uro-Vaxom in recurrent urinary tract infection", Br J Urol, 65, pp.6~9 (1990)
- Chiavaroli C, "An hypothesis to link the opposing immunological effects induced by the bacterial lysate OM-89in urinary tract infection and rheumatoid arthritis", BioDrugs, 20, pp.141~149 (2006)
- Schulman CC, "Oral immunotherapy of recurrent urinary tract infections : a doubleblind placebo-controlled multicenter study", J Urol, 150, pp.917~921 (1993)
- Magasi P, "Uro-Vaxom and the management of recurrent urinary tract infection in adults: a randomized multicenter double-blind trial", Eur Urol, 26, pp.137~140 (1994)
