Type Distribution of Human Papillomavirus in Genital Warts of Korean Men
0
조회
0
다운로드
2
인용
0
참고문헌
키워드
초록
Purpose: To analyze the distribution of human papillomavirus (HPV) types and the characteristics of genital condyloma in Korean men.Materials and Methods: Between January 2015 and December 2015, we reviewed the medical charts of 435 male patients diagnosed with genital condyloma. A total of 441 samples were identified. The detection rate of each HPV type and its associated characteristics (age, number of HPV types, low-risk and/or high-risk types, number of lesions) were analyzed. Our sample population was divided into two groups: The non-urethral condyloma group and the urethral condyloma group. In addition, subgroup analysis was also performed.Results: Among the total 441 specimens, 409 (92.7%) were non-urethral condyloma and 32 (7.3%) were urethral condyloma. Single-type infection was observed in 56.7% and multiple-type infection was seen in 43.3%. HPV type 6 and type 11 were the most common types in total genital condyloma and subgroups. HPV type 11, which was detected in 43.8% of those in the urethral condyloma group and in 22.0% of those in the non-urethral condyloma group (p=0.009), showed a statistically significant difference with respect to the type-specific detection rate.Conclusions: As in previous studies, our study also showed that HPV type 6 was the most prevalent type among all genital condylomas, followed by HPV type 11. A subgroup analysis also showed the same result.
Abstract
Purpose: To analyze the distribution of human papillomavirus (HPV) types and the characteristics of genital condyloma in Korean men.Materials and Methods: Between January 2015 and December 2015, we reviewed the medical charts of 435 male patients diagnosed with genital condyloma. A total of 441 samples were identified. The detection rate of each HPV type and its associated characteristics (age, number of HPV types, low-risk and/or high-risk types, number of lesions) were analyzed. Our sample population was divided into two groups: The non-urethral condyloma group and the urethral condyloma group. In addition, subgroup analysis was also performed.Results: Among the total 441 specimens, 409 (92.7%) were non-urethral condyloma and 32 (7.3%) were urethral condyloma. Single-type infection was observed in 56.7% and multiple-type infection was seen in 43.3%. HPV type 6 and type 11 were the most common types in total genital condyloma and subgroups. HPV type 11, which was detected in 43.8% of those in the urethral condyloma group and in 22.0% of those in the non-urethral condyloma group (p=0.009), showed a statistically significant difference with respect to the type-specific detection rate.Conclusions: As in previous studies, our study also showed that HPV type 6 was the most prevalent type among all genital condylomas, followed by HPV type 11. A subgroup analysis also showed the same result.
참고문헌 (23)
- Giuliano AR, "Epidemiology and pathology of HPV disease in males", Gynecol Oncol, 117(2Suppl), pp.S15~S19 (2010)
- de Villiers EM, "Classification of papillomaviruses", Virology, 324, pp.17~27 (2004)
- Juckett G, "Human papillomavirus: clinical manifestations and prevention", Am Fam Physician, 82, pp.1209~1213 (2010)
- zur Hausen H, "Papillomaviruses in the causation of human cancers-a brief historical account", Virology, 384, pp.260~265 (2009)
- Antonio Jimenez-Pacheco, "Meta-Analysis of Studies Analyzing the Role of Human Papillomavirus in the Development of Bladder Carcinoma", Investigative and Clinical Urology, 53(4), pp.240~247 (2012), 대한비뇨기과학회
- Canepa P, "HPV related diseases in males: a heavy vaccine-preventable burden", J Prev Med Hyg, 54, pp.61~70 (2013)
- Oriel JD, "Natural history of genital warts", Br J Vener Dis, 47, pp.1~13 (1971)
- Garland SM, "Natural history of genital warts: analysis of the placebo arm of 2 randomized phase III trials of a quadrivalent human papillomavirus (types 6, 11, 16, and 18) vaccine", J Infect Dis, 199, pp.805~814 (2009)
- Arroyo LS, "Distribution of genital human papillomavirus genotypes in benign clinical manifestations among men from Northern Spain", BMC Public Health, 16, pp.81~ (2016)
- Aynaud O, "Developmental factors of urethral human papillomavirus lesions: correlation with circumcision", BJU Int, 84, pp.57~60 (1999)
- Aguilar LV, "Human papillomavirus in men: comparison of different genital sites", Sex Transm Infect, 82, pp.31~33 (2006)
- Watson RA, "Human papillomavirus: confronting the epidemica urologist’s perspective", Rev Urol, 7, pp.135~144 (2005)
- Pudney J, "Innate and acquired immunity in the human penile urethra", J Reprod Immunol, 88, pp.219~227 (2011)
- Egawa N, "Human papillomaviruses;epithelial tropisms, and the development of neoplasia", Viruses, 7, pp.3863~3890 (2015)
- Anic GM, "Incidence and human papillomavirus (HPV) type distribution of genital warts in a multinational cohort of men:the HPV in men study", J Infect Dis, 204, pp.1886~1892 (2011)
- 박성진, "Prevalence and Determinants of High-Risk Human Papillomavirus Infection in Male Genital Warts", Investigative and Clinical Urology, 55(3), pp.207~212 (2014), 대한비뇨기과학회
- Freire MP, "Genital prevalence of HPV types and co-infection in men", Int Braz J Urol, 40, pp.67~71 (2014)
- Salehi-Vaziri M, "The prevalence and genotype distribution of human papillomavirus in the genital tract of males in Iran", Jundishapur J Microbiol, 8, pp.e21912~ (2015)
- 권택민, "Multiple Human Papillomavirus Infection Is Associated with High-Risk Infection in Male Genital Warts in Ulsan, Korea", Journal of Korean Medical Science, 31(3), pp.371~375 (2016), 대한의학회
- Dunne EF, "Prevalence of HPV infection among men: a systematic review of the literature", J Infect Dis, 194, pp.1044~1057 (2006)
- Albero G, "Male circumcision and the incidence and clearance of genital human papillomavirus (HPV) infection in men: the HPV Infection in men (HIM) cohort study", BMC Infect Dis, 14, pp.75~ (2014)
- Taylor S, "The incidence, clearance and persistence of non-cervical human papillomavirus infections: a systematic review of the literature", BMC Infect Dis, 16, pp.293~ (2016)
- Kjaer SK, "Acquisition and persistence of human papillomavirus infection in younger men: a prospective follow-up study among Danish soldiers", Cancer Epidemiol Biomarkers Prev, 14, pp.1528~1533 (2005)
