본문 바로가기
KERD
논문KCI 등재

Differential effects of various dietary proteins on dextran sulfate sodium-induced colitis in mice

2

조회

0

다운로드

0

인용

0

참고문헌

키워드

초록

BACKGROUND/OBJECTIVES: Chronic colitis is a risk factor for colorectal cancer (CRC) development in both animals and humans. Previously, we reported that a diet rich in protein (with casein as the protein source) significantly increased the risk of mouse CRC development in a dose-dependent manner. In this study, we investigated the effects of different protein sources on the risk of colitis development. MATERIALS/METHODS: Balb/c mice were divided into 7 experimental groups: 20% casein (20C), 20C-dextran sulfate sodium (DSS), 40% casein-DSS (40CD), 40% whey protein-DSS (40WD), 40% soy protein-DSS (40SD), 40% white meat-DSS (40WMD), and 40% red meat-DSS (40RMD). Mice were fed an experimental diet for 4 wk and received 3% DSS in their drinking water for 6 days during the 4th wk of the experimental period. RESULTS: Compared to other groups, the 40CD group showed the most aggravated colitis with increased disease activity and inflammatory markers. In the 40RMD group, interleukin (IL)-6 levels were the highest among all the groups. The 40SD group showed conflicting effects, for example, elevated mortality and disease activity but decreased nitric oxide (NO) levels. The 40WD group showed attenuated colitis with increased IL-10 levels and decreased NO levels. The 40WMD group showed conflicting effects, including decreased NO levels and elevated fecal lipocalin-2 and IL-6 levels. CONCLUSIONS: These results suggest that, at levels of 40% in the diet, casein and red meat exacerbate colitis, whereas whey protein mitigates it the most effectively.

Abstract

BACKGROUND/OBJECTIVES: Chronic colitis is a risk factor for colorectal cancer (CRC) development in both animals and humans. Previously, we reported that a diet rich in protein (with casein as the protein source) significantly increased the risk of mouse CRC development in a dose-dependent manner. In this study, we investigated the effects of different protein sources on the risk of colitis development. MATERIALS/METHODS: Balb/c mice were divided into 7 experimental groups: 20% casein (20C), 20C-dextran sulfate sodium (DSS), 40% casein-DSS (40CD), 40% whey protein-DSS (40WD), 40% soy protein-DSS (40SD), 40% white meat-DSS (40WMD), and 40% red meat-DSS (40RMD). Mice were fed an experimental diet for 4 wk and received 3% DSS in their drinking water for 6 days during the 4th wk of the experimental period. RESULTS: Compared to other groups, the 40CD group showed the most aggravated colitis with increased disease activity and inflammatory markers. In the 40RMD group, interleukin (IL)-6 levels were the highest among all the groups. The 40SD group showed conflicting effects, for example, elevated mortality and disease activity but decreased nitric oxide (NO) levels. The 40WD group showed attenuated colitis with increased IL-10 levels and decreased NO levels. The 40WMD group showed conflicting effects, including decreased NO levels and elevated fecal lipocalin-2 and IL-6 levels. CONCLUSIONS: These results suggest that, at levels of 40% in the diet, casein and red meat exacerbate colitis, whereas whey protein mitigates it the most effectively.

참고문헌 (37)

  1. Molodecky NA, "Environmental risk factors for inflammatory bowel disease", Gastroenterol Hepatol(N Y), 6, pp.339~346 (2010)
  2. Keshteli AH, "Diet in the pathogenesis and management of ulcerative colitis; a review of randomized controlled dietary interventions", Nutrients, 11, pp.1498~ (2019)
  3. Benchimol EI, "Inflammatory bowel disease in immigrants to Canada and their children : a population-based cohort study", Am J Gastroenterol, 110, pp.553~563 (2015)
  4. Mantovani A, "Cancer-related inflammation", Nature, 454, pp.436~444 (2008)
  5. Kim YH, "Piceatannol, a stilbene present in grapes, attenuates dextran sulfate sodium-induced colitis", Int Immunopharmacol, 8, pp.1695~1702 (2008)
  6. Byun SY, "Curcumin ameliorates the tumor-enhancing effects of a high-protein diet in an azoxymethane-induced mouse model of colon carcinogenesis", Nutr Res, 35, pp.726~735 (2015)
  7. Lan A, "Dual effects of a high-protein diet on DSS-treated mice during colitis resolution phase", Am J Physiol Gastrointest Liver Physiol, 311, pp.G624~G633 (2016)
  8. 탁가희, "Increase in dietary protein content exacerbates colonic inflammation and tumorigenesis in azoxymethane-induced mouse colon carcinogenesis", Nutrition Research and Practice, 11(4), pp.281~289 (2017), 한국영양학회
  9. Vidal-Lletjós S, "Dietary protein and amino acid supplementation in inflammatory bowel disease course : what impact on the colonic mucosa?", Nutrients, 9, pp.310~ (2017)
  10. van Nuenen MH, "The metabolic activity of fecal microbiota from healthy individuals and patients with inflammatory bowel disease", Dig Dis Sci, 49, pp.485~491 (2004)
  11. Jiang H, "Soy protein diet, but not Lactobacillus rhamnosus GG, decreases mucin-1, trefoil factor-3, and tumor necrosis factor-α in colon of dextran sodium sulfate-treated C57BL", 6 mice, 2011, pp.141, 1239~1246
  12. McIntosh GH, "Dairy proteins protect against dimethylhydrazine-induced intestinal cancers in rats", J Nutr, 125, pp.809~816 (1995)
  13. Belobrajdic DP, "Whey proteins protect more than red meat against azoxymethane induced ACF in Wistar rats", Cancer Lett, 198, pp.43~51 (2003)
  14. Pandurangan AK, "Gallic acid attenuates dextran sulfate sodium-induced experimental colitis in BALB", c mice, 2015, pp.9, 3923~3934
  15. PfafflMW, "A new mathematical model for relative quantification in real-time RT-PCR", Nucleic Acids Res, 29, pp.e45~ (2001)
  16. Han X, "A fast and accurate way to determine short chain fatty acids in mouse feces based on GC-MS", J Chromatogr B Analyt Technol Biomed Life Sci, 1099, pp.73~82 (2018)
  17. Chassaing B, "Fecal lipocalin 2, a sensitive and broadly dynamic non-invasive biomarker for intestinal inflammation", PLoS One, 7, pp.e44328~ (2012)
  18. Mouillé B, "Adaptative increase of ornithine production and decrease of ammonia metabolism in rat colonocytes after hyperproteic diet ingestion", Am J Physiol Gastrointest Liver Physiol, 287, pp.G344~G351 (2004)
  19. Topping DC, "Synthesis of macromolecules by intestinal cells incubated with ammonia", Am J Physiol, 233, pp.E341~E347 (1977)
  20. Ichikawa H, "Stimulation of epithelial cell proliferation of isolated distal colon of rats by continuous colonic infusion of ammonia or short-chain fatty acids is nonadditive", J Nutr, 128, pp.843~847 (1998)
  21. Cremin JD Jr, "Glucose alleviates ammonia-induced inhibition of short-chain fatty acid metabolism in rat colonic epithelial cells", Am J Physiol Gastrointest Liver Physiol, 285, pp.G105~G114 (2003)
  22. Le Leu RK, "Dietary red meat aggravates dextran sulfate sodium-induced colitis in mice whereas resistant starch attenuates inflammation", Dig Dis Sci, 58, pp.3475~3482 (2013)
  23. McIntosh GH, "The influence of dietary proteins on colon cancer risk", Nutr Res, 21, pp.1053~1066 (2001)
  24. Shi J, "High-meat-protein high-fat diet induced dysbiosis of gut microbiota and tryptophan metabolism in Wistar rats", J Agric Food Chem, 68, pp.6333~6346 (2020)
  25. Ronis MJ, "Whey protein hydrolysate but not whole whey protein protects against 7, 12-dimethylbenz(a)anthracene-induced mammary tumors in rats", Nutr Cancer, 67, pp.949~953 (2015)
  26. Yu Y, "Soy isoflavone consumption and colorectal cancer risk : a systematic review and meta-analysis", Sci Rep, 6, pp.25939~ (2016)
  27. Guo YW, "Soy saponins meditate the progression of colon cancer in rats by inhibiting the activity of β-glucuronidase and the number of aberrant crypt foci but not cyclooxygenase-2 activity", ISRN Oncol, 2013, pp.645817~ (2013)
  28. Govers MJ, "Dietary soybean protein compared with casein damages colonic epithelium and stimulates colonic epithelial proliferation in rats", J Nutr, 123, pp.1709~1713 (1993)
  29. Pan L, "The influences of soybean agglutinin and functional oligosaccharides on the intestinal tract of monogastric animals", Int J Mol Sci, 19, pp.554~ (2018)
  30. Badger TM, "Developmental effects and health aspects of soy protein isolate, casein, and whey in male and female rats", Int J Toxicol, 20, pp.165~174 (2001)
  31. Daniel CR, "Prospective investigation of poultry and fish intake in relation to cancer risk", Cancer Prev Res(Phila), 4, pp.1903~1911 (2011)
  32. Ollberding NJ, "Meat consumption, heterocyclic amines and colorectal cancer risk : the Multiethnic Cohort Study", Int J Cancer, 131, pp.E1125~E1133 (2012)
  33. Samraj AN, "A red meat-derived glycan promotes inflammation and cancer progression", Proc Natl Acad Sci U S A, 112, pp.542~547 (2015)
  34. Zhu Y, "Meat, dairy and plant proteins alter bacterial composition of rat gut bacteria", Sci Rep, 5, pp.15220~ (2015)
  35. Thibault R, "Down-regulation of the monocarboxylate transporter 1 is involved in butyrate deficiency during intestinal inflammation", Gastroenterology, 133, pp.1916~1927 (2007)
  36. Kostovcikova K, "Diet rich in animal protein promotes pro-inflammatory macrophage response and exacerbates colitis in mice", Front Immunol, 10, pp.919~ (2019)
  37. Thibault R, "Butyrate utilization by the colonic mucosa in inflammatory bowel diseases : a transport deficiency", Inflamm Bowel Dis, 16, pp.684~695 (2010)

관련 논문AI추천

Increase in dietary protein content exacerbates colonic inflammation and tumorigenesis in azoxymethane-induced mouse colon carcinogenesis김은정, 안은영, 탁가희한국영양학회 · Nutrition Research and Practice2017 · 제11권 제4호Effect of vitamin C on azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced colitis-associated early colon cancer in mice김유리, 김유선, 김은주, 석푸름, 신재호, 염이슬, 우문재, 전희진한국영양학회 · Nutrition Research and Practice2018 · 제12권 제2호Effects of natural raw meal (NRM) on high-fat diet and dextran sulfate sodium (DSS)-induced ulcerative colitis in C57BL/6J mice박건영, 박명규, 박미현, 신성호, 황성주, Jiale Song한국영양학회 · Nutrition Research and Practice2015 · 제9권 제6호Açaí Berries Inhibit Colon Tumorigenesis in Azoxymethane/Dextran Sulfate Sodium-Treated Mice김나영, 남령희, 서영준, 이동호, 이선민, 이하나, 이혜승, 최윤정, 최윤진거트앤리버 소화기연관학회협의회 · Gut and Liver2017 · 제11권 제2호Effects of 17β-Estradiol on Colonic Permeability and Inflammation in an Azoxymethane/Dextran Sulfate Sodium-Induced Colitis Mouse ModelChin-Hee Song, Dong Ho Lee, Hee Young Na, Nayoung Kim, Ryoung Hee Nam, Sung Hwa Sohn, Sun Min Lee, Young-Joon Surh거트앤리버 소화기연관학회협의회 · Gut and Liver2018 · 제12권 제6호Alloferon Alleviates Dextran Sulfate Sodium-induced Colitis강재승, 김주성, 김혜민, 이왕재, 임종필대한면역학회 · Immune Network2015 · 제15권 제3호

이 간행물의 다른 논문 (9건)