전연령 중증도별 식품알레르기의 주요 원인: 단일기관 최근 10년 후향적 조사 연구
Causes of food allergy according to age and severity: A recent 10-year retrospective study from a single tertiary hospital
1
조회
0
다운로드
9
인용
0
참고문헌
키워드
초록
Purpose: Recent studies of food allergy (FA) at all ages are scanty in Korea. We performed this study to better understand severity-related and age-stratified causes of FA from infants to older adults in a single tertiary hospital in Korea. Methods: A retrospective medical record review was performed on patients of all ages diagnosed with immediate-type FA between March 2008 and February 2018 in Ajou University Hospital. Results: A total of 4,680 cases of FA among 2,733 patients were reported. The distribution of onset ages of the first FA symptom was as follows: 45.3% below 2 years, 16.2% at 2–6 years, 5.5% at 7–12 years, 4.0% at 13–18 years, 16.9% at 19–40 years, 10.4% at 41–65 years, and 1.8% above 65 years of age. The major 10 causative foods were hen’s eggs (17.2%), cow’s milk (16.7%), wheat (8.6%), crustaceans (8.5%), fish (4.6%), walnuts (4.4%), pork (3.2%), peanuts (3.2%), shellfish (3.0%), and peach (2.2%). The culprits ranked from the 11th to the 20th were as follows: soybean, apple, chicken, buckwheat, beef, kiwi, almonds, perilla seeds, tomato, and squid. The top 3 causative foods in children were hen’s eggs, cow’s milk, and wheat, while those in adults were crustaceans, wheat, and fish. Food-induced anaphylaxis was reported in 29.2% of all cases, with cow’s milk, hen’s eggs, wheat, crustaceans, fish, walnuts, pork, shellfish, buckwheat, and peanuts being the major 10 causes. Conclusion: This study could provide a better understanding of the detailed ranks of the causes of FA according to severity and age in Korea.
Abstract
Purpose: Recent studies of food allergy (FA) at all ages are scanty in Korea. We performed this study to better understand severity-related and age-stratified causes of FA from infants to older adults in a single tertiary hospital in Korea. Methods: A retrospective medical record review was performed on patients of all ages diagnosed with immediate-type FA between March 2008 and February 2018 in Ajou University Hospital. Results: A total of 4,680 cases of FA among 2,733 patients were reported. The distribution of onset ages of the first FA symptom was as follows: 45.3% below 2 years, 16.2% at 2–6 years, 5.5% at 7–12 years, 4.0% at 13–18 years, 16.9% at 19–40 years, 10.4% at 41–65 years, and 1.8% above 65 years of age. The major 10 causative foods were hen’s eggs (17.2%), cow’s milk (16.7%), wheat (8.6%), crustaceans (8.5%), fish (4.6%), walnuts (4.4%), pork (3.2%), peanuts (3.2%), shellfish (3.0%), and peach (2.2%). The culprits ranked from the 11th to the 20th were as follows: soybean, apple, chicken, buckwheat, beef, kiwi, almonds, perilla seeds, tomato, and squid. The top 3 causative foods in children were hen’s eggs, cow’s milk, and wheat, while those in adults were crustaceans, wheat, and fish. Food-induced anaphylaxis was reported in 29.2% of all cases, with cow’s milk, hen’s eggs, wheat, crustaceans, fish, walnuts, pork, shellfish, buckwheat, and peanuts being the major 10 causes. Conclusion: This study could provide a better understanding of the detailed ranks of the causes of FA according to severity and age in Korea.
참고문헌 (40)
- Loh W, "The epidemiology of food allergy in the global context", Int J Environ Res Public Health, 15(9), pp.E2043~ (2018)[DOI]
- Fierro V, "Food labeling issues in patients with severe food allergies : solving a hamlet-like doubt", Curr Opin Allergy Clin Immunol, 17, pp.204~211 (2017)
- 전유훈, "국내 알레르기 유발식품 표시제의 현황과 문제점", Allergy Asthma & Respiratory Disease, 7(2), pp.67~72 (2019), 대한 소아알레르기 호흡기학회
- Prescott S, "Food allergy : riding the second wave of the allergy epidemic", Pediatr Allergy Immunol, 22, pp.155~160 (2011)
- 정경욱, "Age- Based Causes and Clinical Characteristics of Immediate-Type Food Allergy in Korean Children", Allergy, Asthma & Immunology Research, 9(5), pp.423~430 (2017), 대한천식알레르기학회
- Savage J, "Food allergy : epidemiology and natural history", Immunol Allergy Clin North Am, 35, pp.45~59 (2015)
- Elizabeth Huiwen Tham, "How Different Parts of the World Provide New Insights Into Food Allergy", Allergy, Asthma & Immunology Research, 10(4), pp.290~299 (2018), 대한천식알레르기학회
- 민택기, "국내 소아 식품알레르기의 역학", Allergy Asthma & Respiratory Disease, 6(1), pp.4~13 (2018), 대한 소아알레르기 호흡기학회[DOI]
- Nwaru BI, "Prevalence of common food allergies in Europe : a systematic review and meta-analysis", Allergy, 69, pp.992~1007 (2014)
- Willits EK, "Food allergy : a comprehensive population-based cohort study", Mayo Clin Proc, 93, pp.1423~1430 (2018)
- Poulos LM, "Trends in hospitalizations for anaphylaxis, angioedema, and urticaria in Australia, 1993-1994 to 2004-2005", J Allergy Clin Immunol, 120, pp.878~884 (2007)
- Turner PJ, "Increase in anaphylaxis-related hospitalizations but no increase in fatalities : an analysis of United Kingdom national anaphylaxis data, 1992-2012", J Allergy Clin Immunol, 135, pp.956~963 (2015)
- 이상철, "Clinical Features and Culprit Food Allergens of Korean Adult Food Allergy Patients: A Cross-Sectional Single-Institute Study", Allergy, Asthma & Immunology Research, 11(5), pp.723~735 (2019), 대한천식알레르기학회
- 이소희, "A Retrospective Study of Korean Adults With Food Allergy: Differences in Phenotypes and Causes", Allergy, Asthma & Immunology Research, 9(6), pp.534~539 (2017), 대한천식알레르기학회
- Simons FE, "World Allergy Organization Anaphylaxis Guidelines : 2013 update of the evidence base", Int Arch Allergy Immunol, 162, pp.193~204 (2013)
- 김민지, "Prevalence of Immediate-Type Food Allergy in Korean Schoolchildren in 2015: A Nationwide, Population-based Study", Allergy, Asthma & Immunology Research, 9(5), pp.410~416 (2017), 대한천식알레르기학회
- 김영호, "지난 20여 년간 서울지역 초등학생 식품알레르기 유병률의 변화와 위험 인자 분석", Allergy Asthma & Respiratory Disease, 4(4), pp.276~283 (2016), 대한 소아알레르기 호흡기학회[DOI]
- Sicherer SH, "Food allergy : Epidemiology, pathogenesis, diagnosis, and treatment", J Allergy Clin Immunol, 133, pp.291~307 (2014)
- Crespo JF, "Frequency of food allergy in a pediatric population from Spain", Pediatr Allergy Immunol, 6, pp.39~43 (1995)
- Imamura T, "A survey of patients with self-reported severe food allergies in Japan", Pediatr Allergy Immunol, 19, pp.270~274 (2008)
- Koplin JJ, "The impact of family history of allergy on risk of food allergy : a population-based study of infants", Int J Environ Res Public Health, 10, pp.5364~5377 (2013)
- Patelis A, "Natural history of perceived food hypersensitivity and IgE sensitisation to food allergens in a cohort of adults", PLoS One, 9, pp.e85333~ (2014)
- Ferrari GG, "IgE-mediated food allergies in Swiss infants and children", Swiss Med Wkly, 141, pp.w13269~ (2011)
- Pyrhönen K, "Occurrence of parent-reported food hypersensitivities and food allergies among children aged 1-4 yr", Pediatr Allergy Immunol, 20, pp.328~338 (2009)
- Sampson HA, "Food allergy. Part 1: immunopathogenesis and clinical disorders", J Allergy Clin Immunol, 103, pp.717~728 (1999)
- 이정민, "4세 미만 소아에서 호두 알레르기의 임상 특성과 땅콩과의 교차 반응성 연구", Allergy Asthma & Respiratory Disease, 21(4), pp.261~268 (2011), 대한 소아알레르기 호흡기학회
- Ben-Shoshan M, "Is the prevalence of peanut allergy increasing? A 5-year follow-up study in children in Montreal", J Allergy Clin Immunol, 123, pp.783~788 (2009)
- Savage JH, "The natural history of peanut allergy : extending our knowledge beyond childhood", J Allergy Clin Immunol, 120, pp.717~719 (2007)
- Urisu A, "Japanese Society of Pediatric Allergy and Clinical Immunology; Japanese Society of Allergology. Japanese Guideline for Food Allergy 2014", Allergol Int, 63, pp.399~419 (2014)
- Grabenhenrich LB, "Anaphylaxis in children and adolescents : The European Anaphylaxis Registry", J Allergy Clin Immunol, 137, pp.1128~1137 (2016)
- Gupta RS, "The prevalence, severity, and distribution of childhood food allergy in the United States", Pediatrics, 128, pp.e9~e17 (2011)
- 이소연, "A Multicenter Retrospective Case Study of Anaphylaxis Triggers by Age in Korean Children", Allergy, Asthma & Immunology Research, 8(6), pp.535~540 (2016), 대한천식알레르기학회
- Muraro A, "Anaphylaxis : guidelines from the European Academy of Allergy and Clinical Immunology", Allergy, 69, pp.1026~1045 (2014)
- Sampson HA, "Second symposium on the definition and management of anaphylaxis : summary report--Second National Institute of Allergy and Infectious Disease", Food Allergy and Anaphylaxis Network symposium, 2006, pp.117, 391~397
- 예영민, "Predictors of the Severity and Serious Outcomes of Anaphylaxis in Korean Adults: A Multicenter Retrospective Case Study", Allergy, Asthma & Immunology Research, 7(1), pp.22~29 (2015), 대한천식알레르기학회
- Lydia Wong, "Shellfish and House Dust Mite Allergies: Is the Link Tropomyosin?", Allergy, Asthma & Immunology Research, 8(2), pp.101~106 (2016), 대한천식알레르기학회
- Wu TC, "Prevalence of food allergy in Taiwan : a questionnaire-based survey", Intern Med J, 42, pp.1310~1315 (2012)
- Savage JH, "The natural history of egg allergy", J Allergy Clin Immunol, 120, pp.1413~1417 (2007)
- Korea Ministry of Food and Drug Safety, "Allergenic food labeling act 2015", Ministry of Food and Drug Safety, ~ (2015)
- Sicherer SH, "Food allergy : a review and update on epidemiology, pathogenesis, diagnosis, prevention, and management", J Allergy Clin Immunol, 141, pp.41~58 (2018)