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골다공증 쥐에서 우슬의 농도별 투여에 따른 골대사의 생화학적 마커에 미치는 영향

Effect of Biochemical Makers of Bone Metabolism by Administration of Achyrantes Radix Concentration in Ovariectomized Rats

장미경|김영일|김형우|정현우|김용억|김계엽|김은정
한의병리학회 (The Society of Pathology in Korean Medicine)|2007.08|동의생리병리학회지 (Journal of Physiology & Pathology in Korean Medicine)|제21권 제4호|pp. 967-972

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참고문헌

주제분류한의학

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Abstract

Osteoporosis is the most prevalent metabolic bone disease and is characterized by diminished bone strength predisposing to an increased risk of fracture. We investigated the effects of the extract from Acyranthes Radix on the progress of bone loss in ovariectomized rats for 6 weeks. Female Sprague-Dawley 40 rats of 3-4 weeks, weight 200 ± 10g were divided into two groups including the sham operation group(8 rats) and ovariectomy group(32 rats). The dose-dependent effect of Acyranthes Radix extract on bone mineral density and biochemical testing was assessed in ovariectomized rat. Body weights were increased in all groups was higher in experimental group than sham operation group. The level of bone mineral density, GPT, and serum P concentration, ALP were increased experimental group, but a little increase in sham operation group at same period. This longitudinal study result made conclusion that Acyranthes Radix extract treatment appeared to improve the osteoporosis delaying the progression to the osteoporotic process in rats.

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